Portable XRF Technology to Quantify Pb in Bone In Vivo.
Portable XRF Technology to Quantify Pb in Bone In Vivo.
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DOI：
10.1155/2014/398032
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Nie LH
中科院分区：
文献类型：
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作者：
Specht AJ;Weisskopf M;Nie LH
铅是一种无处不在的有毒物质。骨铅已被确定为累积铅暴露的重要生物标志物，并与人体许多系统的不良健康影响相关。k壳x射线荧光（KXRF）是测量骨铅的标准方法，但该方法存在许多困难，限制了该暴露评估方法的广泛应用。随着x射线荧光（XRF）技术的最新进展，我们开发了一种便携式系统，可以在3分钟内定量体内骨骼中的铅。我们的研究探讨了系统的改进，四种校准方法，以及体内测量的系统验证。我们的主要研究结果表明，该系统在2 mm软组织厚度下的检出限为2.9 ppm，在体测量的最佳校准方法为背景减法，KXRF与便携式LXRF骨铅结果之间存在较强的相关性。我们的研究结果表明，该技术已准备好用于大规模人群研究，以调查铅暴露对健康的不利影响。该系统的便携性和快速测量时间应使该技术能够大大推进铅暴露和公共/环境健康的研究。
Lead is a ubiquitous toxicant. Bone lead has been established as an important biomarker for cumulative lead exposures and has been correlated with adverse health effects on many systems in the body. K-shell X-ray fluorescence (KXRF) is the standard method for measuring bone lead, but this approach has many difficulties that have limited the widespread use of this exposure assessment method. With recent advancements in X-ray fluorescence (XRF) technology, we have developed a portable system that can quantify lead in bone in vivo within 3 minutes. Our study investigated improvements to the system, four calibration methods, and system validation for in vivo measurements. Our main results show that the detection limit of the system is 2.9 ppm with 2 mm soft tissue thickness, the best calibration method for in vivo measurement is background subtraction, and there is strong correlation between KXRF and portable LXRF bone lead results. Our results indicate that the technology is ready to be used in large human population studies to investigate adverse health effects of lead exposure. The portability of the system and fast measurement time should allow for this technology to greatly advance the research on lead exposure and public/environmental health.