Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.
Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.
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发表时间：
1989-07
影响因子：
4.4
通讯作者：
William L. Haynes;A. Proia;Gordon K. Klintworth
中科院分区：
文献类型：
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作者：
William L. Haynes;A. Proia;Gordon K. Klintworth
我们使用计算机图像分析来定量评估局部应用皮质类固醇的能力（地塞米松磷酸钠、醋酸泼尼松龙）、环氧合酶抑制剂（氟比洛芬、吲哚美辛、酮咯酸）、脂氧合酶抑制剂（REV 5901，escuaoke，槲皮素）和双重环氧合酶/脂氧合酶抑制剂（BW 755 C，BW A540 C），以减少银/硝酸钾烧灼诱导的大鼠角膜新生血管。皮质类固醇和环氧合酶抑制剂可显著降低新生血管反应。对来自每个类别的代表性化合物进行完整的剂量-反应曲线。发现地塞米松在减少该模型中新生血管形成的能力方面上级氟比洛芬，而即使在高剂量下，也未观察到REV 5901或BW 755 C的显著抑制作用。我们的结论是，在这个模型中的角膜血管生成反应可以减少抑制环氧合酶以及其他机制是类固醇依赖性的，但到目前为止，定义不清。
We used computerized image analysis to evaluate quantitatively the ability of topically applied corticosteroids (dexamethasone sodium phosphate, prednisolone acetate), cyclooxygenase inhibitors (flurbiprofen, indomethacin, ketorolac), lipoxygenase inhibitors (REV 5901, esculetin, quercetin), and dual cyclooxygenase/lipoxygenase inhibitors (BW 755C, BW A540C) to reduce corneal neovascularization in the rat induced by silver/potassium nitrate cauterization. Significant decreases in the neovascular response were found with corticosteroids and cyclooxygenase inhibitors. A complete dose-response curve was performed for a representative compound from each class. Dexamethasone was found to be superior to flurbiprofen in its ability to reduce neovascularization in this model, while no significant inhibition was noted with either REV 5901 or BW 755C, even at high doses. We conclude that the corneal angiogenic response in this model can be reduced by inhibition of cyclooxygenase as well as by other mechanisms that are steroid-dependent but are, as yet, poorly defined.