DTP AND DTP-INACTIVATED POLIO VACCINES - COMPARISON OF ADVERSE REACTIONS AND IGG, IGM AND IGA ANTIBODY-RESPONSES TO DTP
DTP AND DTP-INACTIVATED POLIO VACCINES - COMPARISON OF ADVERSE REACTIONS AND IGG, IGM AND IGA ANTIBODY-RESPONSES TO DTP
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DOI：
10.1111/j.1651-2227.1980.tb07056.x
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
PELTONEN, T
中科院分区：
文献类型：
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作者：
RUUSKANEN, O;VILJANEN, MK;PELTONEN, T
对DTP或DTP灭活脊髓灰质炎疫苗接种儿童的不良反应和抗DTP [白喉-破伤风-百日咳]抗体[Ab]应答进行了比较。材料包括380名儿童，其不良反应通过向家长发放详细的问卷进行登记。采用酶联免疫吸附试验（ELISA）测定42例儿童抗DTP-Ab的IG [免疫球蛋白] G-、IgM-和IgA-。发热、躁动和局部反应是观察到的最常见的不良反应。DTP-脊髓灰质炎疫苗比DTP诱导更多的躁动。这是两种疫苗之间不良反应的唯一显著差异。在6月龄时IgG-抗-DTP Ab应答增强。在DTP-脊髓灰质炎组中观察到。这种增强在抗毒素反应中是短暂的，但在8个月时仍然存在于百日咳抗体中。年龄。在两组中均观察到IgM和IgA抗DTP抗体水平极低且大多数检测不到。
Adverse reactions and anti-DTP [diphtheria-tetanus-pertussis] antibody [Ab] responses were compared between DTP- or DTP-inactivated polio-vaccinated children. The material consisted of 380 children whose adverse reactions were registered by detailed questionnaires given to the parents. Ig[immunoglobulin]G-, IgM- and IgA-anti-DTP Ab of 42 children were quantified using enzyme-linked immunosorbent assay (ELISA). Fever, restlessness and local reactions were the most frequent adverse reactions observed. DTP-polio vaccine induced significantly more restlessness than DTP. This was the only significant difference in adverse reactions between the vaccines. An enhancement of IgG-anti-DTP Ab responses at the age of 6 mo. was observed in the DTP-polio group. The enhancement was transient in antitoxin responses but still present in pertussis Ab at 8 mo. of age. Very low and mostly undetectable levels of IgM- and IgA-anti-DTP Ab were observed in both groups.