PET and the effects of aging and neurodegeneration on brain function: basic principles.
PET and the effects of aging and neurodegeneration on brain function: basic principles.
复制标题
PET 以及衰老和神经退行性变对大脑功能的影响：基本原理。
DOI：
10.1358/dnp.1998.11.3.863652
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发表时间：
1998
影响因子：
--
通讯作者：
H. Hampel
中科院分区：
文献类型：
--
作者：
P. Pietrini;S. Teipel;P. Bartenstein;S. Rapoport;H. Möller;H. Hampel
在关于正电子发射断层扫描（PET）在人脑神经变性和衰老研究中的作用的三部分系列文章的第一部分中，作者回顾了体内脑功能测量的历史发展，导致PET技术的最新进展。概述了PET扫描的物理原理和该技术的固有局限性，为第二部分和第三部分中提出的PET数据的关键解释以及在不同生理和病理条件下对大脑进行的PET研究的数量不断增加奠定了基础。最后，作者描述了用[（18）F]-FDG PET测量体内局部脑葡萄糖代谢、局部脑血流量以及神经受体的分布和结合能力的能力。他们的结论与PET技术的未来前景及其相关性，特别是神经精神病学研究。
In the first part of a three-part series on the role of positron emission tomography (PET) in the study of neurodegeneration and aging in the human brain, the authors review the historical development of the in vivo measurement of brain function resulting in recent advances in PET technology. An overview is presented of the physical principles of PET scanning and the inherent limitations of this technology to set the basis for the critical interpretation of PET data presented in the second and third parts and in the ever-increasing number of PET studies on the brain in different physiological and pathological conditions. Finally, the authors describe the ability to measure in vivo regional cerebral glucose metabolism with [(18)F]-FDG PET, regional cerebral blood flow and the distribution and binding capacity of neuroreceptors. They conclude with future perspectives of PET technology and its relevance, especially for neuropsychiatric research.