Associations Between Internalizing Symptoms and Trajectories of Medication Adherence Among Pediatric Renal and Liver Transplant Recipients
Associations Between Internalizing Symptoms and Trajectories of Medication Adherence Among Pediatric Renal and Liver Transplant Recipients
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DOI：
10.1093/jpepsy/jsq014
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发表时间：
2010-10-01
影响因子：
3.6
通讯作者：
Steele, Ric G.
中科院分区：
文献类型：
--
作者：
Wu, Yelena P.;Aylward, Brandon S.;Steele, Ric G.
目的 检查儿科人群移植后的药物依从轨迹以及依从轨迹与自我报告的内化症状之间的关联。方法 采用多层次模型检查 55 名接受肝肾移植的儿童和青少年的内化症状和纵向用药依从性，并通过电子监测进行评估。结果 在研究评估窗口期间，药物依从性普遍下降，较高水平的焦虑与较高且更稳定的药物依从性模式相关。结论 在评估和干预移植后药物依从性时，焦虑可能是一个需要考虑的重要因素。未来的研究应考虑依从性监测的潜在反应效应，以及与可能影响依从性的焦虑相关的个人和家庭行为。
Objectives To examine medication adherence trajectories posttransplantation and the association between adherence trajectories and self-reported internalizing symptoms in a pediatric population. Methods Multilevel modeling was used to examine internalizing symptoms and longitudinal medication adherence, as assessed by electronic monitoring, among 55 children and adolescents who received liver or kidney transplantation. Results Medication adherence generally declined over the study assessment window, and higher levels of anxiety were associated with higher and more stable patterns of medication adherence. Conclusions Anxiety may be an important factor to consider when assessing and intervening with posttransplantation medication adherence. Future research should consider the potential reactivity effects of adherence monitoring, as well as individual and family behaviors associated with anxiety that may influence adherence.