Homologs of Drosophila appendage genes in the patterning of arthropod limbs
Homologs of Drosophila appendage genes in the patterning of arthropod limbs
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DOI：
10.1006/dbio.2000.9904
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发表时间：
2000-11-15
影响因子：
2.7
通讯作者：
Kaufman, TC
中科院分区：
文献类型：
--
作者：
Abzhanov, A;Kaufman, TC
对果蝇附肢模式相关基因的研究揭示了负责指定近远端肢体轴的信号传导和转录调节系统。在这里，我们报告了果蝇基因外齿、腊肠犬、nubbin、缺乏腹静脉（又名 Cf1-a）和 DII 的假定同源物在土虱 Porcellio scaber 和蜘蛛 Steatoda triangulosa 的四肢中的表达模式。尽管附属物基因的表达域与果蝇的表达域大致对应，但它们的相对位置和节段隶属关系是不同的。此外，附属物基因的表达模式可以解析甲壳类动物和蜘蛛胚胎中不同附属物的节段组成。我们得出的结论是，某些肢体类型，例如口器，似乎是通过中间和远端足节的消除/融合而衍生自类似腿的地面平面。此外，我们在斑斑虾的前腿转变为口器的过程中观察到了这种变化。尽管我们的数据并没有明确解决节肢动物腿节的同源性问题，但它们确实为非昆虫节肢动物肢体发育中单一保守的近远端模式系统提供了证据。 (C) 2000 年学术出版社。
Studies of the genes involved in patterning the appendages of Drosophila melanogaster have revealed a system of signaling and transcriptional regulation that is responsible for specifying the proximo-distal limb axis. Here we report the expression patterns of presumptive homologs of the Drosophila genes extradenticle, dachshund, nubbin, ventral veins lacking (a.k.a. Cf1-a), and DII in the limbs of the woodlouse Porcellio scaber and the spider Steatoda triangulosa. Although the expression domains of the appendage genes roughly correspond to those of Drosophila, their relative positions and segmental affiliation are distinct. In addition, the expression patterns of the appendage genes allows a resolution of the segmental composition of different appendages within crustacean and spider embryos. We conclude that certain limb types, e.g., mouthparts, appear to be derived from a leg-like ground-plan via the elimination/fusion of the intermediate and distal podomeres. Moreover, we observe lust such a modification during the transformation of the anterior legs into mouthparts in P. scaber. Although our data do not unequivocally resolve the question of homology of the arthropod leg segments, they do provide evidence for a single conserved proximo-distal patterning system in the development of noninsect arthropod limbs. (C) 2000 Academic Press.