Effects of ondansetron in early-versus late-onset alcoholics: A prospective, open-label study
Effects of ondansetron in early-versus late-onset alcoholics: A prospective, open-label study
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DOI：
10.1097/01.alc.0000075547.77464.76
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发表时间：
2003-07-01
期刊：
影响因子：
--
通讯作者：
Hernandez-Avila, C
中科院分区：
文献类型：
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作者：
Kranzler, HR;Pierucci-Lagha, A;Hernandez-Avila, C
背景：早发性酒精中毒（EOAs）具有更大的酒精中毒家族负荷，更严重的疾病进展，更严重的合并症。精神病理，并且对治疗的反应比晚发性酗酒者（LOAs）差。昂丹司琼是一种5-羟色胺-3拮抗剂，在治疗eoa方面优于安慰剂，但在治疗loa方面优于安慰剂。本研究比较了口服昂丹司琼溶液在eoa和loa中的耐受性和潜在疗效。方法：40例酒精依赖门诊患者（男性67.5%，欧美87.5%，eoa 20例，loa 20例）口服昂丹司琼溶液，剂量为4杯/kg，每日2次，连续8周，同时每周进行预防复发治疗。结果：与loa相比，eoa每天的饮酒量、每个饮酒日的饮酒量和酒精相关问题显著减少。缺乏碳水化合物的转铁蛋白水平的变化与自我报告的饮酒行为的变化是一致的。结论：口服昂丹司琼溶液似乎适合治疗酒精依赖，其结果与安慰剂对照试验的证据一致，即剂量为4马克杯/公斤，每天两次的昂丹司琼对治疗eoa有价值。
Background: Early-onset alcoholics (EOAs) have a greater familial loading for alcoholism, more severe progression of the disorder, a greater severity of comorbild. psychopathology, and a poorer response to treatment than late-onset alcoholics (LOAs). Ondansetron, a 5-hydroxytryptamine-3-antagonist, was found to be superior to placebo in the treatment of EOAs, but not of LOAs. This study compared the tolerability, and potential efficacy of an oral solution of ondansetron in EOAs versus LOAs.Methods: Forty outpatients with alcohol dependence (67.5% male; 87.5% European American; 20 EOAs; 20 LOAs) received an oral solution of ondansetron at a dosage of 4 mug/kg twice daily for 8 weeks, together with weekly relapse-prevention therapy.Results: EOAs had a significantly greater decrease in drinks per day, drinks per drinking day, and alcohol-related problems than LOAs. Changes in the level, of carbohydrate-deficient transferrin were consistent with changes in self-reported drinking behavior.Conclusions: An oral solution of ondansetron seems suitable for the treatment of alcohol dependence, yielding findings consistent with evidence from a placebo-controlled trial that ondansetron, at a dosage of 4 mug/kg twice daily, is of value in the treatment of EOAs.