PHYSICAL-ACTIVITY AND 10.5 YEAR MORTALITY IN THE MULTIPLE RISK FACTOR INTERVENTION TRIAL (MRFIT)
PHYSICAL-ACTIVITY AND 10.5 YEAR MORTALITY IN THE MULTIPLE RISK FACTOR INTERVENTION TRIAL (MRFIT)
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DOI：
10.1093/ije/20.3.690
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发表时间：
1991-09-01
影响因子：
7.7
通讯作者：
CONNETT, J
中科院分区：
文献类型：
--
作者：
LEON, AS;CONNETT, J
对参加MRFIT的12138名冠心病高危中年男性，研究了习惯性闲暇时间体力活动(LTPA)对10.5年总死亡率和死因分类死亡率的影响。明尼苏达问卷测定的LTPA水平与心血管疾病(CVD)、冠心病(CHD)和全因死亡率呈负相关，但与癌症死亡率无关。最不活跃的男性(LTPA三分位数1)的心血管疾病、冠心病和各种原因的额外死亡率分别为22%、27%和15%，而活动较多的男性(三分位数2)的死亡率较高。额外的LTPA(三分一)与死亡率的进一步降低无关。比例风险回归分析仅略微削弱了风险差异。这项研究支持了先前的观察，即定期的LTPA与心血管疾病死亡率的降低有关，与其他危险因素水平无关。
The effect of habitual leisure time physical activity (LTPA) on the 10.5-year total and cause-specific mortality rates was studied in 12 138 middle-aged men at high risk for coronary heart disease (CHD) who participated in the MRFIT. The level of LTPA as determined by the Minnesota questionnaire was inversely related to rate of death from cardiovascular (CVD), coronary heart disease (CHD), and all-causes, but was unrelated to the cancer death rate. The least active men (LTPA tertile 1) had excess mortality rates of 22%, 27%, and 15% for CVD, CHD, and all-causes, respectively, as compared to more active men in the middle third (tertile 2). Additional LTPA (tertile 3) was not associated with further attenuation of mortality rates. Proportional hazards regression analysis only slightly weakened risk differentials. This study supports previous observations that regular LTPA is associated with a reduced rate of CVD mortality, independent of other risk factor levels.