The Association of Life Stress With Substance Use Symptoms: A Network Analysis and Replication
The Association of Life Stress With Substance Use Symptoms: A Network Analysis and Replication
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DOI：
10.1037/abn0000485
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发表时间：
2020-02-01
影响因子：
4.6
通讯作者：
Eaton, Nicholas R.
中科院分区：
文献类型：
--
作者：
Lin, Sin-Ying;Fried, Eiko, I;Eaton, Nicholas R.
越来越多的证据强调生活压力是物质使用障碍 (SUD) 发生和复发的危险因素，但生活压力与 SUD 症状之间相互作用的关系却被忽视了。当前的研究使用美国国家酒精及相关疾病流行病学调查 (NESARC) I 和 II (N = 34,653) 的代表性数据，调查了生活压力在 3 种不同 SUD（酒精、烟草和吸毒）症状网络中的作用。使用 Ising 模型和 l1 正则化以及基于扩展贝叶斯信息准则的模型选择来估计症状网络。我们研究了压力与 2 个网络特征的关联：网络连接性和网络结构。此外，我们应用引导例程来检查我们结果的稳定性，并测试我们在第 1 波中的发现是否在 NESARC 的第 2 波中得到了复制。对于酒精和吸毒症状，但对于烟草使用症状，更大的网络连接性（与精神严重程度和预后相关）与压力源的数量相关。相比之下，无论压力水平如何，SUD症状网络的结构都保持稳定，这表明症状网络中中心节点的顺序与压力没有显着相关。总而言之，我们的研究结果表明，与生活压力相关的酒精和吸毒症状关系存在定量（即更大的连通性）而非定性（即结构）差异。
A growing body of evidence highlights the role of life stress as a risk factor for the development and relapse of substance use disorders (SUDs), but the relationship of life stress with the interactions among SUD symptoms is overlooked. The current study investigated the role of life stress in symptom networks of 3 different SUDs-alcohol, tobacco, and drug use-using the U.S. representative data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) I and II (N = 34,653). The symptom networks were estimated using the Ising model and l1-regularziation with model selection based on the Extended Bayesian Information Criterion. We examined the association of stress with 2 network characteristics: the network connectivity and the network structure. In addition, we applied bootstrap routines to examine the stability of our results and tested whether our findings of Wave 1 replicated in Wave II of the NESARC. For alcohol and drug use symptoms, but not for tobacco use symptoms, greater network connectivity (which is related to psychiatric severity and prognosis) was associated with the number of stressors. In contrast, the structure of SUD symptom networks remained stable regardless of the level of stress, which indicated that the order of central nodes in the symptom networks was not significantly associated with stress. Altogether, our findings suggest that there is a quantitative (i.e., greater connectivity), but not qualitative (i.e., structure), difference in alcohol and drug use symptom relationships associated with life stress.