Fibrin phantom for use in optical coherence tomography
Fibrin phantom for use in optical coherence tomography
复制标题
DOI：
10.1117/1.3427249
复制
发表时间：
2010-05-01
影响因子：
3.5
通讯作者：
Sampson, David D.
中科院分区：
文献类型：
--
作者：
Kennedy, Brendan F.;Loitsch, Susanne;Sampson, David D.
这项工作提出了一种新的模拟组织体模，用于一系列光学相干断层扫描(OCT)实验。这种幻影在OCT新技术的开发和评估中是至关重要的，但之前发表的幻影还没有被普遍接受。我们提出了第一个基于纤维蛋白矩阵的体模描述，这改进了以前发表的方法的关键属性。它提供了一种生物相容的、光学透明的支架，可以在其中结合有机和/或无机光学散射材料。它的制作时间明显短于许多常见的体模，寿命长于其他生物兼容的体模。展示了含有Intralipid(TM)的纤维蛋白模体引入均匀光学散射的潜力。测量的衰减系数作为Intralipid浓度的函数证实了控制光学散射的能力。文中还提出了一种在每一层中具有明显光学散射的双层体模。(C)2010年光学仪器工程师学会。[DOI：10.1117/1.3427249]
This work presents a novel tissue-mimicking phantom for use in a range of optical coherence tomography (OCT) experiments. Such phantoms are critical in the development and assessment of new OCT techniques, but no previously published phantoms have become universally accepted. We present the first description of a phantom based on a fibrin matrix, which improves key attributes of previously published methods. It provides a biocompatible, optically transparent scaffold in which to incorporate organic and/or inorganic optical scattering materials. Its fabrication time is markedly shorter than many common phantoms, and its lifetime is longer than other biocompatible phantoms. The potential of fibrin phantoms incorporating Intralipid (TM) to introduce uniform optical scattering is demonstrated. The measured attenuation coefficient as a function of Intralipid concentration confirms the ability to control optical scattering. A bilayer phantom with distinct optical scattering in each layer is also presented. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3427249]