Postsynaptic spinal alpha-adrenoceptors mediate effects of intrathecal clonidine.
Postsynaptic spinal alpha-adrenoceptors mediate effects of intrathecal clonidine.
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突触后脊髓α-肾上腺素受体介导鞘内可乐定的作用。
DOI：
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发表时间：
1981
影响因子：
5
通讯作者：
L. Finch
中科院分区：
文献类型：
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作者：
H. Connor;L. Finch
用6-羟基多巴胺或5，6-二羟色胺处理脊髓去甲肾上腺素或5-羟色胺，观察鞘内注射可乐定对心血管的影响。尽管脊髓去甲肾上腺素或5-羟色胺水平显著降低，但静息血压和心率没有变化，可乐定引起的低血压和心动过缓没有受到影响。结果提示，鞘内可乐定通过位于节前神经元胞体突触后的抑制性脊髓α-肾上腺素能受体起作用。
The cardiovascular effects of intrathecal administration of clonidine were examined after depletion of spinal cord noradrenaline or 5-hydroxytryptamine by pretreatment with 6-hydroxydopamine or 5,6-dihydroxytryptamine. Despite marked reduction in spinal noradrenaline or 5-hydroxytryptamine levels, resting blood pressure and heart rate were unchanged and the clonidine-induced hypotension and bradycardia were unimpaired. The results suggest that intrathecal clonidine acts via inhibitory spinal alpha-adrenoceptors located postsynaptically on the preganglionic nerve cell bodies.