Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both
Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both
复制标题
DOI：
10.1016/s0735-1097(98)00584-1
复制
发表时间：
1999-02-01
影响因子：
24
通讯作者：
Drexler, H
中科院分区：
文献类型：
--
作者：
Heitzer, T;Herttuala, SY;Drexler, H
本研究的目的是检验长期补充维生素E可改善高胆固醇血症和/或慢性吸烟患者内皮依赖性舒张的假设，这两个危险因素已被证明与自由基形成增加有关。背景实验证据表明，氧化低密度脂蛋白（LDL）损害内皮依赖性舒张，而维生素E，一种脂溶性抗氧化剂，方法13名高胆固醇血症患者，14名吸烟者和15名高胆固醇血症吸烟者参加了一项双盲，安慰剂对照研究。基线测量后，血浆自身抗体对氧化低密度脂蛋白和评估内皮依赖性舒张使用前臂动脉内注入乙酰胆碱，各组内的参与者被随机分配在1：2的时尚接受安慰剂或维生素E 4个月，当血浆水平的自身抗体对氧化低密度脂蛋白和血管功能进行了重新assessed.Results维生素E显着增强内皮依赖性舒张高胆固醇血症的吸烟者，但不是在高胆固醇血症或慢性吸烟的患者。在基线时，高胆固醇血症吸烟者对氧化LDL的自身抗体水平显著较高（与其他两组相比），在补充维生素E 4个月后显著降低。有一个显着的关系，改善乙酰胆碱诱导的血管舒张和自身抗体滴度的变化对氧化低密度脂蛋白（r = -0.59，p = 0.002）。结论长期补充维生素E改善高胆固醇血症吸烟者，其特点是增加水平的自身抗体对氧化低密度脂蛋白的前臂阻力血管内皮依赖性舒张。这些发现可能表明，维生素E的有益作用仅限于氧化LDL暴露增加的受试者。(C)1999年由美国心脏病学会。
OBJECTIVES The purpose of this study was to test the hypothesis that long-term supplementation with Vitamin E improves endothelium-dependent relaxation in hypercholesterolemia patients and/or chronic smoking, two risk factors that have been shown to be associated with increased radical formation.BACKGROUND Experimental evidence suggests that oxidized low density lipoprotein (LDL) impairs endothelium-dependent relaxation, and vitamin E, a lipid-soluble antioxidant, reduces the oxidation of LDL.METHODS Thirteen subjects with hypercholesterolemia, 14 smokers and 15 hypercholesterolemic smokers were enrolled in a double-blind, placebo-controlled study. After baseline measurements of plasma autoantibodies against oxidized LDL and assessment of endothelium-dependent relaxation using intra-arterial forearm infusions of acetylcholine, participants within each group were randomly assigned in a 1:2 fashion to receive either placebo or vitamin E for 4 months, when plasma levels of autoantibodies against oxidized LDL and vascular function were reassessed.RESULTS Vitamin E significantly augmented endothelium-dependent relaxation in hypercholesterolemic smokers but not in patients with either hypercholesterolemia or chronic smoking. At baseline, hypercholesterolemic smokers had significantly higher autoantibody levels against oxidized LDL (compared with the other two groups), which were significantly reduced after 4 months of vitamin E supplementation. There was a significant relationship between improvement in acetylcholine-induced vasodilation and the change in autoantibody titer against oxidized LDL (r = -0.59; p = 0.002).CONCLUSIONS Long-term vitamin E supplementation improves endothelium-dependent relaxation in forearm resistance Vessels of hypercholesterolemic smokers, which are characterized by increased levels of autoantibodies against oxidized LDL. These findings may suggest that the beneficial effect of vitamin E is confined to subjects with increased exposure to oxidized LDL. (C) 1999 by the American College of Cardiology.