Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.
Kaempferia parviflora extract increases energy consumption through activation of BAT in mice.
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DOI：
10.1002/fsn3.144
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发表时间：
2014-11
影响因子：
3.9
通讯作者：
Kawada, Teruo
中科院分区：
文献类型：
--
作者：
Yoshino, Susumu;Kim, Minji;Awa, Riyo;Kuwahara, Hiroshige;Kano, Yuriko;Kawada, Teruo
小花山奈（KP）是生姜家族的成员，在泰国被称为泰国人参、Krachai Dam或黑姜。K。小花植物提取物（KPE）具有多种生理学效应，但其抗肥胖作用及其机制尚不清楚。本研究采用KPE（低剂量：0.5%KPE，高剂量：1.0%KPE）对小鼠进行减肥实验，以观察KPE的减肥作用。对于0.5%KPE和1.0%KPE，在高脂饮食（HFD）中含有KPE的7周喂养显著降低体重增加、腹内脂肪积累以及血浆甘油三酯和瘦素水平。同时，KPE给药增加了喂食HFD的小鼠的耗氧量。我们还发现，1.0%KPE喂养显着增加解偶联蛋白1（UCP1）在棕色脂肪组织（BAT）的表达。此外，KPE给药增加尿去甲肾上腺素分泌水平。这些结果表明，KPE在两种剂量下通过激活BAT促进能量代谢，在高剂量下通过上调UCP1蛋白。尽管仍存在许多挑战，但本研究表明，KPE通过增加能量代谢抑制HFD诱导的肥胖。
Kaempferia parviflora (KP) is a member of the ginger family and is known in Thailand as Thai ginseng, Krachai Dam or Black Ginger. TheK. parviflora extract (KPE) was previously reported to have a number of physiological effects; however, the antiobesity effects of KPE and its mechanisms remain to be elucidated. In this study, we conducted KPE feeding experiments (low dose: 0.5% KPE, high dose: 1.0% KPE) in mice to examine the antiobesity effects. For both 0.5% KPE and 1.0% KPE, 7 weeks’ feeding of KPE contained in a high-fat diet (HFD) significantly decreased body weight gain, intraabdominal fat accumulation, and plasma triglyceride and leptin levels. Concurrently, KPE administration increased oxygen consumption in mice fed on a HFD. We also found that 1.0% KPE feeding significantly increased the uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT). Moreover, KPE administration increased urinary noradrenaline secretion levels. These results demonstrate that KPE promotes energy metabolism by activation of BAT, at both doses and up-regulation of UCP1 protein at a high dose. Although numerous challenges remain, the present study demonstrated that KPE suppresses HFD-induced obesity through increased energy metabolism.