Focal segmental glomerulosclerosis as a complication of hepatitis B virus infection
Focal segmental glomerulosclerosis as a complication of hepatitis B virus infection
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DOI：
10.1093/ndt/gfq600
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发表时间：
2011-01-01
影响因子：
6.1
通讯作者：
Yamagata, Kunihiro
中科院分区：
文献类型：
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作者：
Sakai, Kentaro;Morito, Naoki;Yamagata, Kunihiro
人类乙肝病毒(HBV)是膜性肾病(MN)的主要病因之一。虽然乙肝病毒感染与MN有很强的相关性，但关于其与其他肾小球疾病的相关性的数据是相互矛盾的。在此，我们报告一例局灶性节段性肾小球硬化(FSGS)合并乙肝病毒感染。在这个病例中，我们用实时荧光定量聚合酶链式反应的方法在尿足细胞中发现了HBVDNA。在给予抗病毒治疗后，FSGS有所改善，与足细胞中HBVDNA水平的下降平行。用适当的抗病毒药物可有效治疗乙肝病毒所致的难治性FSGS。
Human hepatitis B virus (HBV) is well known as a cause of membranous nephropathy (MN). While the association of HBV infection with MN is strong, data regarding its association with other glomerular diseases are conflicting. Here, we report a case of focal segmental glomerulosclerosis (FSGS) with HBV infection. In this case, we have found HBV-DNA in urinary podocytes by real-time PCR methods. After the administration of anti-viral therapy, FSGS improved, paralleling the decreased level of HBV-DNA in podocytes. The refractory FSGS induced by HBV could be effectively treated with appropriate antiviral agents.