Age-acquired immunity to a Plasmodium vivax invasion ligand, the Duffy binding protein
Age-acquired immunity to a Plasmodium vivax invasion ligand, the Duffy binding protein
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DOI：
10.1086/341776
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发表时间：
2002-08-15
影响因子：
6.4
通讯作者：
King, CL
中科院分区：
文献类型：
--
作者：
Cole-Tobian, JL;Cortés, A;King, CL
间日疟原虫merozoite Duffy binding protein region II （DBPII）与人红细胞Duffy抗原相互作用导致感染。该蛋白的高度多态性区域可能作为一种避免宿主免疫的机制而出现。为了研究间日疟原虫免疫是否针对这些DBPII多态性区域，研究人员对358名间日疟原虫阳性巴布亚新几内亚人的特异性DBPII等位基因频率的年龄相关变化进行了研究。虽然同时感染个体的DBPII单倍型的总体数量和多样性随着年龄的增长而下降，但只有特定位点上的某些等位基因频率下降，这表明对这些等位基因的优先免疫选择。一个这样的多态性位点形成了B细胞表位的一部分，暴露个体的抗体在这个位点上识别不同的等位基因。因此，菌株特异性年龄获得性免疫的获得部分针对间日疟原虫DBPII中的多态性基序，这表明这些多态性在宿主的免疫压力下得以维持并可能产生。
The interaction between the Plasmodium vivax merozoite Duffy binding protein region II (DBPII) and the human erythrocyte Duffy antigen leads to infection. Highly polymorphic regions of this protein may have arisen as a mechanism to avoid host immunity. To examine whether immunity to P. vivax is directed against these polymorphic regions of DBPII, age-associated changes in the frequency of specific DBPII alleles among 358 P. vivax-positive Papua New Guineans were examined. Although the overall number and diversity of DBPII haplotypes simultaneously infecting an individual decreased with increasing age, only certain alleles at particular loci declined in frequency, indicating preferential immune selection against these alleles. One such polymorphic locus formed part of a B cell epitope, and antibodies from exposed individuals differentially recognized alleles at this locus. Therefore, acquisition of strain-specific age-acquired immunity is partially directed against polymorphic motifs within P. vivax DBPII, suggesting that these polymorphisms are maintained and likely arose under immune pressure in the host.