Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method
Impact of reversible trapping of tracer and the presence of blood metabolites on measurements of myocardial glucose utilization performed by PET and 18F-fluorodeoxyglucose using the Patlak method
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DOI：
10.1016/j.nucmedbio.2004.03.002
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发表时间：
2004-10-01
影响因子：
3.1
通讯作者：
Gropler, RJ
中科院分区：
文献类型：
--
作者：
Herrero, P;Dence, CS;Gropler, RJ
在这项研究中，我们证明，显着的出口FDG从心肌发生在示踪剂注射后的第一个小时内，导致非线性Patlak图。血液中也存在大量的酸性FDG代谢物。然而，这些代谢产物对心肌葡萄糖利用率（MGU）估计值的影响可忽略不计。尽管需要进一步研究来阐明示踪剂从心肌中流出的原因，但不考虑它将导致MGU的错误估计。(C)2004年爱思唯尔公司All rights reserved.
In this study we demonstrated that significant egress of FDG from myocardium occurs within the first hour after tracer injection leading to nonlinear Patlak plots. There are also significant amounts of acidic FDG metabolites present in the blood. However, the impact of these metabolites on the estimates of myocardial glucose utilization (MGU) is negligible. Although further studies will be required to elucidate the reason for the egress of tracer from myocardium, not accounting for it will result in erroneous estimates of MGU. (C) 2004 Elsevier Inc. All rights reserved.