Access to Oxoquinoline Heterocycles by N-Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone
Access to Oxoquinoline Heterocycles by N-Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone
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DOI：
10.1002/anie.201402620
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发表时间：
2014-06-01
影响因子：
16.6
通讯作者：
Chi, Yonggui Robin
中科院分区：
文献类型：
--
作者：
Fu, Zhenqian;Jiang, Ke;Chi, Yonggui Robin
有机催化的酯活化反应是一种高选择性的饱和酯和氨基烯酮之间的级联反应。该反应涉及作为关键步骤的酯的b-碳原子的活化。该方法允许一步获得具有高对映体比率的多环氧代喹啉型杂环。
Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the b-carbon atom of the ester as a key step. This method allows a single-step access to multicyclic oxoquinoline-type heterocycles with high enantiomeric ratios.