Lunasensor, Infradian Rhythms, Telomeres, and the Chronomere Program of Aging
Lunasensor, Infradian Rhythms, Telomeres, and the Chronomere Program of Aging
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DOI：
10.1196/annals.1356.006
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发表时间：
2005-12
影响因子：
5.2
通讯作者：
A. Olovnikov
中科院分区：
文献类型：
--
作者：
A. Olovnikov
根据redusome假说，生物体的衰老是由染色体（小的染色体周围线性DNA分子）的缩短决定的。在本文中，被认为是一个假定的作用，激素的节律。内源性的日下节律被认为是积极地与那些荷尔蒙的变化，这是由一个外源性的日下重力月球节律。由于这种相互作用，形成了所谓的T节律。T节律的峰值被用作起搏信号，以保持大脑的终身“发条”运行。这个时钟的“滴答声”是通过有丝分裂后神经内分泌细胞中计时器的周期性重复缩短来实现的，这恰好发生在T节律的最大值处。体内有丝分裂细胞中端粒的缩短是机体衰老的见证，但不是衰老的原因。衰老的主要原因是时间点的缩短，时间点是发育和衰老的时间程序的物质载体。为了识别外生引力日节律，一种特殊的生理系统--“月球传感器”系统--进化了。据认为，这是一个必要的lunasensor作为一个特定的变量的传感器的引力。
According to the redusome hypothesis, the aging of an organism is determined by the shortening of chronomeres (small perichromosomal linear DNA molecules). In this paper, a presumptive role for infradian hormonal rhythms is considered. Endogenous infradian rhythms are supposed to actively interact with those hormonal shifts which are governed by an exogenous infradian gravitational lunar rhythm. As a result of this interaction, the so‐called T‐rhythm is formed. Peaks of T‐rhythms are used as the pacemaker signals to keep the life‐long “clockwork” of the brain running. The “ticking” of this clock is realized by the periodically repeated shortening of chronomeres in postmitotic neuroendocrine cells, which occurs just at the maxima of T‐rhythms. Shortening of telomeres in mitotic cells in vivo is a witness of the aging of the organism, but not the cause of aging. The primary cause of aging is shortening of chronomeres, the material carriers of a temporal program of development and aging. To recognize exogenous gravitational infradian rhythms, a special physiological system—the “lunasensor” system—evolved. It is assumed that it is a necessity to have a lunasensor as a particular variant of sensors of gravitation.