IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice.
IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice.
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DOI：
10.1016/j.jneuroim.2015.06.002
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发表时间：
2015-08-15
影响因子：
3.3
通讯作者：
Offner H
中科院分区：
文献类型：
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作者：
Zhang J;Benedek G;Bodhankar S;Lapato A;Vandenbark AA;Offner H
患有多发性硬化症（MS）的女性在怀孕期间通常会经历临床改善，这表明性激素可能在MS中具有治疗作用。我们之前的研究表明，B细胞和PD-L1对E2 （17β-雌二醇）介导的实验性自身免疫性脑脊髓炎（EAE）的保护至关重要。我们在这里证明，与E2/生理盐水处理的PD-L1 - / -小鼠相比，在EAE诱导后将IL-10+ B细胞转移到E2处理的PD-L1 - / -小鼠中，可以部分恢复E2介导的保护作用，并降低中枢神经系统中促炎细胞的频率。因此，IL-10+ B细胞和E2联合给药可能对EAE的治疗具有强大的治疗潜力。
Women with Multiple sclerosis (MS) often experience clinical improvement during pregnancy, indicating that sex hormones might have therapeutic effects in MS. Our previous studies have demonstrated that B cells and PD-L1 are crucial for E2 (17β-estradiol) - mediated protection against experimental autoimmune encephalomyelitis (EAE). We here demonstrate that transfer of IL-10+ B cells into E2-treated PD-L1−/− mice after EAE induction could partially restore E2-mediated protection and decrease the frequency of pro-inflammatory cells in the CNS compared to E2/saline treated PD-L1−/− mice. Hence, co-administration of IL-10+ B cells and E2 might have a powerful therapeutic potential for treatment of EAE.