Propagation of giant migrating contractions between the small intestine, cecum and colon during radiation.
Propagation of giant migrating contractions between the small intestine, cecum and colon during radiation.
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DOI：
10.1111/j.1365-2982.2010.01509.x
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发表时间：
2010-08
影响因子：
3.5
通讯作者：
Moulder JE
中科院分区：
文献类型：
--
作者：
Otterson MF;Leming SC;Fox CJ;Moulder JE
辐射增加小肠和结肠巨大移行性收缩（GMC）的频率。这些收缩导致放射治疗后的腹泻和痉挛，并在回结肠（IC）交界处相互协调。我们研究了5只犬在IC交界处回肠上进行环形肌切开术后小肠、盲肠和结肠之间收缩活动的协调性，并将其与完整动物进行比较。研究在辐射计划之前和期间进行。肌切开术增加了小肠GMC的频率照射前。在完整的动物，盲肠GMC的持续时间和幅度下降时，多次收缩发生在快速连续。这与小肠和结肠GMC形成对比，表明GMC在盲肠内的传播机制不同。回肠肌切开术显著降低了辐射诱导的结肠GMC的传播频率。结肠GMC的总数没有改变。结肠收缩活动中断在完整的动物在照射过程中。然而，回肠切开术后，照射并没有影响结肠收缩状态的模式。与完整的动物相比，切开术的辐照动物的腹泻开始得更早。这可能与小肠GMC的频率有关。我们的研究结果表明，在IC区域的肠神经连接的重要性，小肠和大肠的收缩障碍。犬IC交界处之间的解剖关系与人类回肠-阑尾-结肠区域相似，该区域的手术操作同样可能影响人类收缩活动。
Radiation increases the frequency of small intestinal and colonic giant migrating contractions (GMCs). These contractions contribute to the diarrhea and cramping after radiation therapy and are coordinated with one another across the ileocolonic (IC) junction. We investigated the coordination of contractile activity between the small intestine, cecum and colon in 5 canines following circumferential myotomy on the ileum at the IC junction and compared it to intact animals. Studies were performed before and during a radiation schedule. Myotomy increased the frequency of small intestinal GMCs prior to irradiation. In intact animals, the duration and amplitude of cecal GMCs decreased when multiple contractions occurred in rapid succession. This is in contrast to small intestinal and colonic GMCs and suggests a different mechanism of propagation for GMCs within the cecum. Ileal myotomy dramatically decreased the frequency of propagating radiation induced colonic GMCs. The total number of colonic GMCs was not altered. Colonic contractile activity was disrupted in intact animals during irradiation. However, after ileal myotomy, irradiation did not affect the pattern of colonic contractile states. Diarrhea in irradiated animals with myotomy started earlier than intact animals. This may be related to the frequency of small intestinal GMCs. Our findings suggest importance of the enteric neural connections at the IC region to contractile disorders of both the small and large intestine. The anatomic relationship between the canine IC junction is similar to the human ileo-appendiceal-colonic region and surgical manipulations of this area may likewise affect human contractile activity.