Different sensitization profile for asthma, rhinitis, and eczema among 7-8-year-old children:: Report from the Obstructive Lung Disease in Northern Sweden studies
Different sensitization profile for asthma, rhinitis, and eczema among 7-8-year-old children:: Report from the Obstructive Lung Disease in Northern Sweden studies
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DOI：
10.1034/j.1399-3038.2003.00042.x
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发表时间：
2003-04-01
影响因子：
4.4
通讯作者：
Lundbäck, B
中科院分区：
文献类型：
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作者：
Rönmark, E;Perzanowski, M;Lundbäck, B
对不同空气传播的过敏原与哮喘、鼻炎和湿疹的致敏作用进行了研究。一项横断面研究在瑞典北部7-8岁的儿童中进行。艾萨克问卷连同其他问题被发送给家长，3431人(97%)参与了调查。三分之二的儿童被邀请接受10种常见空气传播过敏原的皮肤测试，其中2148人(88%)参与了测试。在对任何一种测试的过敏原致敏的儿童中，所有三种疾病的患病率都明显较高。在哮喘患者中，40%的人对猫过敏，34%的人对狗过敏，28%的人对马过敏，23%的人对桦树过敏，16%的人对Timothy过敏。鼻炎的相应数字是：猫49%，狗33%，马37%，桦树46%，蒂莫西32%；湿疹：猫29%，狗21%，马15%，桦树20%，蒂莫西11%。只有几个孩子对螨虫或霉菌过敏。这三种疾病的主要危险因素都是1型过敏和家族病史。独立于其他危险因素，对狗(OR 2.4)和马(OR 2.2)致敏是哮喘的显著危险因素。白桦树(OR6.0)、马(OR4.1)和蒂莫西(OR2.8)是鼻炎的显著危险因素，白桦树(OR2.4)、狗(OR2.0)和猫(OR1.6)是湿疹的显著危险因素。尽管疾病有很大的重叠，但哮喘、鼻炎和湿疹的致敏模式不同。对猫的致敏在所有儿童中最常见，但对狗和马的致敏与哮喘的风险最高，对桦树的致敏显示鼻炎和湿疹的最高风险。哮喘、鼻炎和湿疹等常见并存疾病的不同危险因素模式可能表明病因的不同。
Sensitization to different airborne allergens in relation to asthma, rhinitis, and eczema has been studied. A cross-sectional study was performed among 7-8-year-old children living in northern Sweden. The ISAAC-questionnaire with additional questions were sent to the parents, and 3431 (97%) participated. Two-thirds of the children were invited to undergo a skin test with 10 common airborne allergens, and 2148 (88%) participated. The prevalence rates of all three diseases were significantly higher among the children who were sensitized to any of the tested allergens. Among asthmatics, 40% were sensitized to cat, 34% to dog, 28% to horse, 23% to birch and 16% to timothy. The corresponding figures for rhinitis were: cat 49%, dog 33%, horse 37%, birch 46%, timothy 32%; and for eczema: cat 29%, dog 21%, horse 15%, birch 20%, and timothy 11%. Only a few children were sensitized to mites or moulds. The main risk factors for all three diseases were type-1 allergy and a family history of the disease. Independently from other risk factors, sensitization to dog (OR 2.4) and horse (OR 2.2) were significant risk factors for asthma. Sensitization to birch (OR 6.0), horse (OR 4.1), and timothy (OR 2.8) were significant risk factors for rhinitis, while birch (OR 2.4), dog (OR 2.0) and cat (OR 1.6) were significant risk factors for eczema. Despite a large over-lapping of the diseases the pattern of sensitization was different for asthma, rhinitis and eczema. Sensitization to cat was most common among all children, but sensitization to dog and horse was associated with the highest risk for asthma, and sensitization to birch showed the highest risk for rhinitis and eczema. The different risk factor pattern for the often coexisting diseases; asthma, rhinitis, and eczema, may indicate differences in the etiology.