KININS ARE GENERATED DURING EXPERIMENTAL RHINOVIRUS COLDS
KININS ARE GENERATED DURING EXPERIMENTAL RHINOVIRUS COLDS
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DOI：
10.1093/infdis/157.1.133
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发表时间：
1988-01-01
影响因子：
6.4
通讯作者：
GWALTNEY, JM
中科院分区：
文献类型：
--
作者：
NACLERIO, RM;PROUD, D;GWALTNEY, JM
我们通过挑战两种鼻病毒或安慰剂菌株中的志愿者来研究鼻病毒感冒的病理生理。在挑战之前，每4小时一次进行鼻腔灌洗，挑战五天。我们测量了组胺，基因素的水平，[3H] -n-。α.-p------甲基-l-精氨酸甲酯（驯服） - 撒酶活性和白蛋白，并计算了回收的灌洗液中中性粒细胞的数量。既感染又有症状的受试者，表明运动素水平升高（p <.03），驯服 - 酯酶活性（p <.04）和白蛋白（p <.05），以及中性粒细胞的数量（p <.01）。报道的症状总数与基因素浓度的净增加显着相关（r = .549; p <.01），白蛋白（r = .674; p <.001），驯服 - 酯酶活性（r =。 563; p <.005）和中性粒细胞（r = .605; p <.005）。在感染过程中，组胺水平没有变化。在有症状的鼻病毒感染期间（1）基因素，（2）血管通透性增加，（3）嗜碱性粒细胞和肥大细胞不参与，（4）中性粒细胞进入鼻分泌物。
We investigated the pathophysiology of rhinovirus colds by challenging volunteers with either of two strains of rhinovirus or with placebo. Nasal lavages were done before challenge and every 4 h for five days after challenge. We measured the levels of histamine, kinins, [3H]-N-.alpha.-p-tosyl-L-arginine methyl ester (TAME)-esterase activity, and albumin and counted the number of neutrophils in the recovered lavage fluid. Subjects who became both infected and symptomatic showed increases in levels of kinins (P < .03), TAME-esterase activity (P < .04), and albumin (P < .05), as well as in the number of neutrophils (P < .01). The total number of symptoms reported correlated significantly with the net increase in the concentration of kinins (r = .549; P < .01), albumin (r = .674; P < .001), TAME-esterase activity (r = .563; P < .005), and neutrophils (r = .605; P < .005). Levels of histamine did not change during the course of infection. During symptomatic rhinovirus infections (1) kinins are generated, (2) vascular permeability increases, (3) basophils and mast cells do not participate, and (4) neutrophils enter nasal secretions.