Importance of routine histopathological examination of a gallbladder surgical specimen: Unexpected gallbladder cancer
Importance of routine histopathological examination of a gallbladder surgical specimen: Unexpected gallbladder cancer
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DOI：
10.4103/0973-1482.187301
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发表时间：
2018-10-01
影响因子：
1.3
通讯作者：
Hatipoglu, Hamit Sinan
中科院分区：
文献类型：
--
作者：
Dincel, Oguzhan;Goksu, Mustafa;Hatipoglu, Hamit Sinan
前言：胆囊良性疾病行胆道镜检查对胆囊癌的诊断有重要意义。这是通过对手术前未检测到或疑似并发症的患者的切除标本进行病理学检查来完成的。虽然一些中心进行胆囊标本的组织病理学检查的选择性方法，许多中心进行常规检查。方法：回顾2012年1月至2016年2月因胆囊良性疾病行胆囊切除术的病例，对胆囊的病理标本进行调查。我们评估了人口统计学特征及其与病理诊断和意外胆囊癌病例频率的关系。我们报告了额外的治疗和术后恶性肿瘤病例的生存信息。结果：我们回顾了1294例胆囊切除术，平均患者年龄为47.5 ± 14.3岁。最常见的诊断为慢性胆囊炎（92.3%），且年轻患者和女性患者更常见（P < 0.0001）。5名患者（0.4%）被确定患有胆囊癌，这些病例的平均年龄为65.6 ± 18.2岁。2例为2期，2例为3期（B），1例为3期（A）。有没有T-1或T-is tumor.Conclusion：胆囊的常规组织病理学检查是显着的额外的干预措施，在术后期间所需的癌症病例的诊断符合方面的确定。
Introduction: Cholecystectomy performed for benign diseases of the gallbladder is important for the diagnosis of gallbladder cancer. This is done by pathological examination of the removed specimens for patients with no detected or suspected complications before surgery. Although some centers undertake selective approaches for histopathological examination of gallbladder specimens, many centers perform this examination routinely. In our study, we investigated results of pathological examinations carried out on cholecystectomy specimens, in respect to unexpected cases of gallbladder cancer.Methods: We reviewed cholecystectomy cases performed for benign diseases of gallbladder from January 2012 to February 2016 by investigating pathological specimens from the gallbladder. We evaluated demographical properties and their association with the pathological diagnosis and frequency of unexpected gallbladder cancer cases. We reported additional treatment and survival information of the malignancy cases after surgery.Results: We reviewed 1294 cases of cholecystectomy, and the mean patient age was 47.5 +/- 14.3 years. The most frequent diagnosis was chronic cholecystitis (92.3%), and it was more prevalent among younger patients and female sex (P < 0.0001). Five patients (0.4%) were determined to have gallbladder cancer, and the mean age of these cases was 65.6 +/- 18.2 years. Two cases were Stage 2, two cases were Stage 3(B), and one case was Stage 3(A). There was no T-1 or T-is is tumor.Conclusion: Routine histopathological examination of gallbladder is significant with respect to the determination of additional interventions at the postoperative period required for cancer cases coincidentally diagnosed.