Methodology and preliminary results from the neurobiology of late-life depression study.
Methodology and preliminary results from the neurobiology of late-life depression study.
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晚年抑郁症神经生物学研究的方法和初步结果。
DOI：
10.1017/s1041610215001386
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发表时间：
2015
影响因子：
7
通讯作者：
Tennen,HowardA
中科院分区：
文献类型：
--
作者：
Steffens,DavidC;Manning,KevinJ;Wu,Rong;Grady,JamesJ;Fortinsky,RichardH;Tennen,HowardA
BackgroundWe sought to investigate the relationship between neuroticism and depression in an elderly cohort. In this paper, we describe the methods of an National Institute of Mental Health—NIMH-supported study and present findings among the cohort enrolled to date.MethodsWe used the NEO Personality Inventory to assess neuroticism, and we employed several cognitive neuroscience-based measures to examine emotional control.ResultsCompared with a group of 27 non-depressed older control subjects, 33 older depressed subjects scored higher on measures of state and trait anxiety and neuroticism. On our experimental neuroscience-based measures, depressed subjects endorsed more negative words compared with controls on an emotional characterization test. In addition, we found a significant group-by-congruency effect on an emotional interference test where subjects were asked to identify the face's emotional expression while ignoring the words “fear” or “happy” labeled across the face.ConclusionThus, in this preliminary work, we found significant differences in measures of neuroticism and emotional controls among older adults with and without depression.
