In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care
In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care
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DOI：
10.1126/sciadv.1600560
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发表时间：
2016-08-01
期刊：
影响因子：
13.6
通讯作者：
Robbins, Peter A.
中科院分区：
文献类型：
--
作者：
Ciaffoni, Luca;O'Neill, David P.;Robbins, Peter A.
目前还没有令人满意的方法来监测重症监护中的耗氧量。为了解决这一问题，我们采用激光吸收光谱法，以提供测量的O-2，CO2，和水蒸气的气道内每10毫秒的分析仪集成在一个新的呼吸流量计，是一个数量级更精确比其他流量计。这种精确度，加上气体浓度与呼吸流量的精确对准，使得通过O-2浓度和流量的乘积随时间的直接积分来确定O-2消耗成为可能。通过对平衡气体（N2加Ar）流量进行积分并显示该交换接近于零来说明精度。测量的O-2消耗量变化
There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O-2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flowmeter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O-2 consumption by direct integration over time of the product of O-2 concentration and flow. The precision is illustrated by integrating the balance gas (N-2 plus Ar) flow and showing that this exchange was near zero. Measured O-2 consumption changed by