The role of metabolic reprogramming in cancer metastasis and potential mechanism of traditional Chinese medicine intervention.
The role of metabolic reprogramming in cancer metastasis and potential mechanism of traditional Chinese medicine intervention.
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DOI：
10.1016/j.biopha.2022.113376
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
Dong Wang;Fangyuan Wang;Xianbin Kong;Qingbo Li;Haoyang Shi;Shuang Zhao;Wen Li;Y. Li;
中科院分区：
文献类型：
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作者：
Dong Wang;Fangyuan Wang;Xianbin Kong;Qingbo Li;Haoyang Shi;Shuang Zhao;Wen Li;Y. Li;
代谢重编程是癌细胞进展和转移最显着的特征之一。中医药具有多途径、多靶点、多成分的抗肿瘤药理作用和不良反应风险低的优点，已广泛应用于癌症的临床治疗。然而，中药抗肿瘤作用的机制尚不完全清楚，特别是在细胞代谢重编程方面。在这篇综述中，我们总结了葡萄糖、脂质和氨基酸代谢在癌症转移中的作用，这是癌细胞和肿瘤微环境（TME）细胞代谢的关键。此外，我们回顾了大多数生物活性中药化合物通过调节代谢重编程来抑制癌症转移的潜在机制以及使其他抗肿瘤药物敏感的可能性。中药及其生物活性化合物在治疗癌症转移方面具有巨大的临床应用前景。不幸的是，目前人们对中草药及其生物活性化合物对癌细胞代谢重编程的调节作用以及癌症的联合治疗知之甚少。该综述为中药与其他抗肿瘤药物联合调节代谢重编程对抗癌症转移以及成为其他抗肿瘤药物增敏剂的可能性提供了新的见解。
Metabolic reprogramming is one of the most prominent features underlying cancer cells progression and metastasis.Traditional Chinese medicine (TCM) has been widely used in the clinical treatment of cancer, with the advantages of multi-pathway, multi-target, multi-component anti-tumor pharmacological effects and low risk of adverse effects. However, the mechanisms underlying the anti-tumor effects of TCM are not fully understood, especially on cellular metabolic reprogramming. In this review, we summarize the role of glucose, lipid and amino acid metabolism in cancer metastasis, which is key in cancer cells and tumor micro-environment (TME) cell metabolism. Furthermore, we reviewed the potential mechanisms by which, most bioactive TCM compounds suppress cancer metastasis by regulating metabolic reprogramming and the possibility of sensitizing other anti-tumor drugs. TCM and its bioactive compounds have huge prospects for clinical application in the treatment of cancer metastasis. Unfortunately, little is currently known about the regulatory effects of Chinese herbal medicines and their bioactive compounds on the metabolic reprogramming of cancer cells and the combination therapy for cancers. This review provides novel insights into the regulation of metabolic reprogramming by TCM in combination with other anti-tumor drugs against cancer metastasis and the possibility of becoming sensitizers for other anti-tumor drugs.