SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.
SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.
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DOI：
10.1111/j.1601-183x.2009.00495.x
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发表时间：
2009-08
期刊：
影响因子：
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通讯作者：
Ehringer MA
中科院分区：
文献类型：
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作者：
Hoft NR;Corley RP;McQueen MB;Huizinga D;Menard S;Ehringer MA
CHRNA 6和CHRNB 3基因与尼古丁依赖和对尼古丁的早期主观反应有关。在这里，我们提出的证据，使用全国代表性的成年人样本，这一地区也与酒精行为。使用统计遗传学软件FBAT-PC分析了跨越CHRNB 3/A6基因的六个SNP，该软件允许检查多个表型的集合以产生每个SNP的最大可遗传复合表型。使用FBAT-PC测试了六个SNP，包括四种酒精表型：平均饮酒次数，停电，DSM-IV滥用和依赖症状总数，以及戒烟尝试。CHRNA 6中的三个SNP（rs 1072003 p=0.015，rs 892413 p=0.0033和rs 2304297 p=0.012）和CHRNB 3中的一个SNP（rs 13280604 p = 0.0053）与酒精表型的复合物相关。该协会主要是由平均饮酒量驱动的。
The CHRNA6 and CHRNB3 genes have been associated with nicotine dependence and early subjective response to nicotine. Here we present evidence, using a nationally representative sample of adults, that this region is also associated with alcohol behaviors. Six SNPs spanning the CHRNB3/A6 genes were analyzed using the statistical genetics software FBAT-PC, which allows one to examine a collection of multiple phenotypes to generate a maximally heritable composite phenotype for each SNP. The six SNPs were tested using FBAT-PC including four alcohol phenotypes: average number of drinks, blackouts, total number of DSM-IV abuse and dependence symptoms endorsed, and quit attempts. Three SNPs in CHRNA6 (rs1072003 p=0.015, rs892413 p=0.0033, and rs2304297 p=0.012) and one SNPs in CHRNB3 (rs13280604 p = 0.0053) were associated with a composite of the alcohol phenotypes. The association was primarily driven by the average number of drinks.