Effects of anesthetic agents on socially transmitted olfactory memories in mice
Effects of anesthetic agents on socially transmitted olfactory memories in mice
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DOI：
10.1016/j.nlm.2009.10.007
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发表时间：
2010-02-01
影响因子：
2.7
通讯作者：
Kendrick, K. M.
中科院分区：
文献类型：
--
作者：
Burne, T. H. J.;Johnston, A. N. B.;Kendrick, K. M.
老鼠可以从同种动物呼吸中传递的气味线索中学习食物偏好，即使“示范者”被麻醉了。据我们所知，目前还没有研究探讨麻醉“观察者”对社会传递食物偏好（STFP）记忆发展的影响。在实验1中，我们发现2-4个月大的F2 C57 Bl/6x 129 sv雄性和雌性小鼠在暴露于麻醉的示范小鼠5分钟后24小时后进行测试时显示出STFP。在实验2中，观察员小鼠麻醉与Sagatal（60毫克/公斤）之前的“社会互动”优先避免提示的食物时，测试24小时后。这种厌恶不是由于该剂量的Sagatal的任何明显的厌恶效应，因为吃了食物然后被麻醉的小鼠，或者在麻醉时只能闻到食物5分钟的小鼠，没有表现出偏好或厌恶。在第三个实验中，我们发现Sagatal引起的厌恶不是麻醉的一般性质，因为观察者用具有不同作用机制的麻醉药物治疗小鼠产生了不同的结果。Vetalar（200 mg/kg）和Rompun（10 mg/kg）治疗的动物在测试中吃了相似数量的暗示和非暗示食物，表明缺乏学习。Hypnorm（0.5 ml/kg）处理的动物显示出对提示食物的偏好，而Hypnovel（2.5 ml/kg）处理的动物显示出对提示食物的厌恶。这些结果表明，在Sagatal中观察到的食物厌恶不是麻醉剂的一般特性，但似乎仅限于主要作用于GABA能系统的麻醉剂。因此，我们已经表明，在某些条件下，它是可能的麻醉观察小鼠学习的偏好或厌恶的社会联系的嗅觉线索。皇冠版权所有（C）2009由爱思唯尔公司出版。All rights reserved.
Mice can learn a food preference from odor cues transmitted on the breath of a conspecific, even if the "demonstrator" is anesthetized. To our knowledge there are no studies examining the effect of anesthetizing the "observer" on development of memory for socially transmitted food preferences (STFP). In Experiment 1 we found that 2-4 month-old F2 C57Bl/6x129sv male and female mice demonstrated a STFP after a 5 min exposure to an anesthetized demonstrator mouse when tested 24 h later. In Experiment 2, observer mice anesthetized with Sagatal (60 mg/kg) prior to the "social interaction" preferentially avoided the cued food when tested 24 h later. This aversion was not due to any overt aversive effects of this dose of Sagatal because mice that ate the food and were then anesthetized, or could only smell the food for 5 min while anesthetized, showed no preference or aversion. In a third experiment we found that the Sagatal-induced aversion was not a general property of anesthesia because there were varied results produced by observer mice treated with anesthetic drugs with different mechanisms of action. Vetalar (200 mg/kg) and Rompun (10 mg/kg) treated animals ate similar amounts of cued and non-cued food at test, indicating an absence of learning. Hypnorm (0.5 ml/kg) treated animals showed a preference for the cued food whereas those treated with Hypnovel (2.5 ml/kg) showed an aversion to the cued food. These results show that the food aversion observed with Sagatal is not a general property of anesthetic agents, but appears to be restricted to those acting primarily on the GABAergic system. Thus, we have shown that under certain conditions it is possible for an anesthetized observer mouse to learn a preference or aversion of a socially-linked olfactory cue. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.