Pd-catalyzed direct arylation of electron-deficient polyfluoroarenes with aryliodine(III) diacetates
Pd-catalyzed direct arylation of electron-deficient polyfluoroarenes with aryliodine(III) diacetates
复制标题
钯催化缺电子多氟芳烃与芳基碘(III)二乙酸酯的直接芳基化
DOI：
10.1016/j.tetlet.2014.11.033
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发表时间：
2015-01-01
影响因子：
1.8
通讯作者：
Cai, Hu
中科院分区：
文献类型：
--
作者：
Fu, Zhengjiang;Xiong, Qiheng;Cai, Hu
钯催化的缺电子多氟芳烃与易得的芳基碘（III）二乙酸酯的直接芳基化反应具有中等至良好的产率。该方法对甲基、甲氧基、溴、氯、三氟甲基、氰基和醛基表现出良好的功能耐受性。机理研究表明，这种耦合涉及在原位生成的芳基碘从加热促进分解的芳基碘（III）二乙酸酯，然后通过耦合与polyfluoroarenes基板，以提供所需的产品。(C)2014爱思唯尔有限公司版权所有。
A Pd-catalyzed direct arylation of electron-deficient polyfluoroarenes with readily available aryliodine(III) diacetates was developed with moderate to good yields. The process exhibited good functional tolerance with respect to methyl, methoxy, bromo, chloro, trifluoromethyl, cyano, and aldehyde groups. Mechanistic studies revealed this coupling involved in situ generation of aryl iodide from heating-promoted decomposition of aryliodine(III) diacetate, followed by coupling with polyfluoroarenes substrates to afford the desired products. (C) 2014 Elsevier Ltd. All rights reserved.