Effect of some Kampo medicines,including Tokaku-joki-to
Effect of some Kampo medicines,including Tokaku-joki-to
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一些汉方药物的功效，包括特觉定吉汤
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
I. Saiki
中科院分区：
文献类型：
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作者：
Tomohiro Yamada;I. Saiki
以往的研究表明，用抗DNP IgE抗体被动致敏的小鼠，在DNFB攻击后1h出现了一种由IgE介导的双相皮肤反应，即立即相反应（IPR），24 h出现了一种晚期相反应（LPR我们最近发现，具有强烈和持续的嗜酸性粒细胞浸润的第三相炎症反应，称为极晚期反应（vLPR），在被动致敏小鼠中，vLPR在攻击后第8天达到高峰。汉方药物对三相皮肤炎症反应的抑制作用根据其对耳肿胀的抑制率分为几组。桃核承气汤对IPR、LPR和vLPR均有抑制作用（+/+/+组）和抓挠行为。Tokaku-joki-to对三相皮肤反应的抑制作用主要取决于其组成的cmde dmgs，甘草和升麻皮。这些
Previous studies have reported that the mice passively sensitized with anti－DNP IgE antibody exhibited IgRmediated biphasic cutaneous reaction with an immediate phase response（IPR）at l h and a late phase response（LPR）at24h after the challenge of DNFB（dinitrofluorobenzene）．We recently found that the third phase inflammatory response with intense and persisting infiltration of eosinophils， named very late phase response（vLPR），was induced following IPR and LPR in response to DNFB in passively sensitized mice，and that the peak response of vLPR was on the8th day after the challenge． The inhibitory effect of Kampo medicines on the triphasic cutaneous inflammatory reaction was divided into several groups in terms of their inhibition rate of ear swelling．Among the formulations，Tokaku－ joki－to（Tao－He－Cheng－Qi－Tang）was effective at inhibiting IPR，LPR and vLPR（＋／＋／＋group） and scratching behavior in IPR．The Inhibitory effect of Tokaku－joki－to on triphasic cutaneous reaction primarily depends on its composed cmde dmgs，Glycyrrhizae Radix and Cimamomi Cortex．These