Does the stressed patient with chronic fatigue syndrome hyperventilate?
Does the stressed patient with chronic fatigue syndrome hyperventilate?
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DOI：
10.1207/s15327558ijbm0301_6
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发表时间：
1996-01-01
影响因子：
2.7
通讯作者：
Tapp, WN
中科院分区：
文献类型：
--
作者：
Lavietes, MH;Natelson, BH;Tapp, WN
因为急性换气过度的症状（例如，疲劳、头痛）和慢性疲劳综合征（CFS）患者的主诉相似，这些病症之间可能存在相关性。本研究试图确定CFS患者是否在安静呼吸或压力下出现高血压。两个参与者组进行了比较：一组包括10名符合CFS既定标准的患者;另一组包括9名在年龄，性别和社会经济地位方面与患者匹配的对照参与者。在整个研究中，参与者坐着并通过吹口安静地呼吸。在心理社会和化学（吸入5%CO2 + 95%O2）应激源之前、期间和之后，监测分钟通气量（V-e）、潮气末CO2（PetCO 2）和心率。使用了两种心理压力源：计算任务和社会评估任务。为了评估每个患者对呼吸困难的感知，进行了改良的博格量表问卷调查。除了PetCO 2外，所有测量的变量在压力源前在患者和正常人中相似;参与者的PetCO 2显著低于对照组（p <0.025）。V-e、博格评分和PetCO 2不受心理应激的影响;呼吸频率在应激期间确实显著增加，但仅限于对照组。相比之下，患者组的心率增加比对照组更一致。在CO2刺激期间，两组之间的通气量没有差异。这些数据表明，CFS患者在休息时是低碳酸血症。我们将正常通气定义为正常碳酸血症;因此，CFS高血压患者。然而，由于患者和对照组在潮气呼吸期间的V-e以及对CO2和实验室应激源的缓解反应相似，因此过度通气的原因尚不清楚。
Because the symptoms of acute hyperventilation (e.g., fatigue, headaches) and the complaints of patients with chronic fatigue syndrome (CFS) are similar, a relation may exist between these conditions. This study attempted to identify whether patients with CFS hyperventilate while breathing quietly or under stress. Two participant groups were compared: One comprised 10 patients who met the established criteria for CFS; the other comprised 9 control participants matched to patients with respect to age, sex, and socioeconomic status. Participants sat and breathed quietly through a mouthpiece for the entire study, Minute ventilation (V-e), end-tidal CO2 (PetCO2), and heart rate were monitored before, during, and after presentation of psychosocial and chemical (inspiration of 5% CO2 + 95% O2) stressors. Two psychological stressors were used: a computational and a socioevaluative task. To evaluate each patient's perception of dyspnea, a modified Borg scale questionnaire was administered, All the variables measured except PetCO2 were similar in patients and normals before stressors; PetCO2 of participants was significantly less than controls (p < .025). V-e, Borg scores, and PetCO2 were not altered by psychological stress; respiratory rate did increase significantly during stress but only for the control group. In contrast, increases in heart rate occurred more consistently in the patient group than in controls. Ventilatory output did not differ between groups during CO2 stimulation. These data show that patients with CFS are hypocapnic at rest. We define normal ventilation as eucapnia; therefore, patients with CFS hyperventilate. However, because V-e during tidal breathing as well as the ventilatory responses to both CO2 and lab stressors were similar in patients and controls, the reason for hyperventilation is unclear.