Sculpting with stiffness: rigidity as a regulator of morphogenesis.
Sculpting with stiffness: rigidity as a regulator of morphogenesis.
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DOI：
10.1042/bst20220826
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发表时间：
2023-06-28
影响因子：
3.9
通讯作者：
Mayor, Roberto
中科院分区：
文献类型：
--
作者：
Shellard, Adam;Mayor, Roberto
从物理角度来看，组织的形态发生是其材料特性与施加在其上的机械力之间相互作用的结果。机械力在影响细胞行为方面的重要性已得到广泛认可，而体内组织材料特性（如刚度）的重要性近年来才开始受到关注。在这篇简短的评论中，我们重点介绍了与组织刚度（一种基本材料特性）如何指导生物体中各种形态发生过程相关的关键主题和概念。
From a physical perspective, morphogenesis of tissues results from interplay between their material properties and the mechanical forces exerted on them. The importance of mechanical forces in influencing cell behaviour is widely recognised, whereas the importance of tissue material properties in vivo, like stiffness, has only begun to receive attention in recent years. In this mini-review, we highlight key themes and concepts that have emerged related to how tissue stiffness, a fundamental material property, guides various morphogenetic processes in living organisms.