Increasing incidence of type 1 diabetes in 0-to 17-year-old Colorado youth
Increasing incidence of type 1 diabetes in 0-to 17-year-old Colorado youth
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DOI：
10.2337/dc06-1837
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发表时间：
2007-03-01
期刊：
影响因子：
16.2
通讯作者：
Dabelea, Dana
中科院分区：
文献类型：
--
作者：
Vehik, Kendra;Hamman, Richard F.;Dabelea, Dana
目的-我们试图评估1型糖尿病发病率的长期趋势，在非西班牙裔白色和西班牙裔青年，年龄0-17岁，从科罗拉多使用数据从科罗拉多胰岛素依赖型糖尿病研究登记处（1978-1988）和糖尿病在青年（2002 - 2004）研究设计和方法-糖尿病病例通过医生报告和医院数据库确定。1型糖尿病被定义为在诊断后2周内使用胰岛素。确定的完整性估计为97%。计算各时间段的年平均发病率（每100，000/年）和95% CI。结果：科罗拉多州1978-1988年和2002-2004年的1型糖尿病发病率分别为14.8（95%CI 14.0-15.6）和23.9（22.2-25.6）（P < 0.0001）。从1978年到2004年，1型糖尿病的发病率每年增加2.3%（1.6-3.1）（P < 0.0001）。非西班牙裔白色人（每年2.7% [95%CI 1.9-3.61]，P < 0.0001）和西班牙裔青年（每年1.6% [0.2-3.1]，P = 0.013）的发病率显著增加。结论：从1978-1988年到2002-2004年，科罗拉多青年的1型糖尿病发病率增加了1.6倍，非西班牙裔白色和西班牙裔青年都受到这一趋势的影响。
OBJECTIVE - We sought to assess the long-term trends in the incidence of type 1 diabetesamong non-Hispanic white and Hispanic youth aged 0-17 years from Colorado using data from the Colorado IDDM Study Registry (1978-1988) and SEARCH for Diabetes in Youth (20022004).RESEARCH DESIGN AND METHODS - Cases of diabetes were ascertained through physician reporting and hospital databases. Type 1 diabetes was defined as use of insulin within 2 weeks from diagnosis. Completeness of ascertainment was estimated as 97%. Annual average incidence rates (per 100,000/year) and 95% CIs for the time periods were computed. Trends in incidence were assessed by Poisson regression.RESULTS - The incidence of type 1 diabetes was 14.8 (95% CI 14.0-15.6) in 1978-1988 and 23.9 (22.2-25.6) in 2002-2004 for the state of Colorado (P < 0.0001). From 1978 to 2004, the incidence of type 1 diabetes increased by 2.3% (1.6-3.1) per year (P < 0.0001). The increase in incidence was significant for both non-Hispanic white (2.7% [95% CI 1.9-3.61 per year, P < 0.0001) and Hispanic youth (1.6% [0.2-3.1] per year, P = 0.013). CONCLUSIONS - The incidence of type 1 diabetes has increased 1.6-fold among Colorado youth from 1978-1988 to 2002-2004, and both non-Hispanic white and Hispanic youth are affected by this trend.