Association of Mass Treatment with Azithromycin in Trachoma-Endemic Communities with Short-Term Reduced Risk of Diarrhea in Young Children
Association of Mass Treatment with Azithromycin in Trachoma-Endemic Communities with Short-Term Reduced Risk of Diarrhea in Young Children
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DOI：
10.4269/ajtmh.2011.11-0046
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发表时间：
2011-10-01
影响因子：
3.3
通讯作者：
West, Sheila
中科院分区：
文献类型：
--
作者：
Coles, Christian L.;Seidman, Jessica C.;West, Sheila
一项队列研究旨在评估用于控制沙眼的阿奇霉素(MDA)的质量分布对坦桑尼亚农村8个社区6个月儿童腹泻发病率的影响。向沙眼患病率为10%的四个社区的所有居民提供单剂阿奇霉素。四个地理上匹配的社区沙眼患病率为10%，没有接受丙二醛治疗。所有随机选择的儿童(n=1036)在MDA术后进行为期6个月的随访，并在家中进行双周监测。在0-1个月和1-3个月期间，在调整了分组和协变量后，暴露于丙二醛的人群与未暴露的人群相比，腹泻风险分别降低了39%(比率比=0.61，95%可信区间=0.39-0.95)和24%(比率比=0.76，95%可信区间=0.54-1.07)。在3-6个月期间，腹泻发病率在不同组之间是相似的。因此，丙二醛与儿童腹泻发病率的短期降低有关。
A cohort study was designed to assess the impact of mass distribution of azithromycin (MDA) for trachoma control on incidence over six months of pediatric diarrhea in eight communities in rural Tanzania. A single dose of azithromycin was offered to all residents in four communities, where trachoma prevalence was >= 10%. Four geographically matched communities had trachoma prevalences < 10% and did not receive MDA. All randomly selected children (n = 1036) were followed-up for six months post-MDA with bi-weekly surveillance at home. In the 0-1-month and 1-3-month periods, MDA exposure was associated with a 39% (rate ratio = 0.61, 95% confidence interval = 0.39-0.95) and 24% (rate ratio = 0.76,95% confidence interval = 0.54-1.07) lower risk of diarrhea, respectively, compared with those unexposed, after adjustment for clustering and covariates. By the 3-6-month period, diarrhea incidence was comparable between groups. Thus, MDA was associated with a short-term reduction in diarrheal morbidity in children.