Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
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伯氨喹类似物在小鼠模型中是有效的抗克氏锥虫药物。
DOI：
10.1080/00034983.1996.11813071
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发表时间：
1996
影响因子：
--
通讯作者：
V. B. Waits
中科院分区：
文献类型：
--
作者：
K. Kinnamon;B. Poon;W. Hanson;V. B. Waits
评估了 77 种伯氨喹类似物在减少 15 天前感染巴西克氏锥虫株的雌性白化小鼠（4-6 周龄）体内寄生虫血症方面的有效性。在测试的类似物中，有 23 种比参考药物硝呋莫司更有效，其中一种的有效性是标准药物的 14 倍以上，活性几乎是伯氨喹本身的四倍。该系列的某些成员经过测试值得进一步评估。
Seventy-seven primaquine analogues were evaluated for their effectiveness in reducing the parasitaemias in female albino mice (aged 4-6 weeks) which had been infected with a Brazilian strain of Trypanosoma cruzi 15 days earlier. Of the analogues tested, 23 were more effective than the reference drug, nifurtimox, and one was > 14-fold as effective as the standard and almost four times as active as primaquine itself. Certain members of the series tested warrant further evaluation.