Dose of radiation received by the bulb of the penis correlates with risk of impotence after three-dimensional conformal radiotherapy for prostate cancer
Dose of radiation received by the bulb of the penis correlates with risk of impotence after three-dimensional conformal radiotherapy for prostate cancer
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DOI：
10.1016/s0090-4295(01)00940-2
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发表时间：
2001-05-01
期刊：
影响因子：
2.1
通讯作者：
Roach, M
中科院分区：
文献类型：
--
作者：
Fisch, BM;Pickett, B;Roach, M
目标。评估阴茎球部剂量对辐射后效力的影响。方法。 21 名在三维适形放射治疗前报告效力的患者评估了输送到阴茎球部的剂量。然后将其与患者治疗后性功能的评估进行比较，以确定是否存在剂量-体积关系。结果。在迄今为止分析的患者中，似乎存在很强的剂量-体积关系以及治疗后保持有效的可能性。阴茎球部 70% 接受低于 40 Gy 剂量的患者似乎更有可能保持效力。阴茎球部 70% 接受 70 Gy 或以上照射的患者出现辐射引起的阳痿的风险似乎非常高 (P = 0.03)。结论。需要更多的研究来证实这些观察结果。如果得到证实，这些数据表明，通过使用基于三维的治疗计划和精心设计的治疗区域，接受放射治疗的男性的疗效可能会得到显着提高。泌尿学 57: 955-959, 2001。(C) 2001，爱思唯尔科学公司。
Objectives. To evaluate the effect of the dose to the bulb of the penis on postradiation potency.Methods. Twenty-one patients reporting potency before three-dimensional conformal radiotherapy had the dose delivered to the bulb of the penis evaluated. This was then compared with the patient assessments of post-treatment sexual function to determine whether a dose-volume relationship exists.Results. Among the patients analyzed to date, a strong dose-volume relationship and the likelihood of remaining potent after treatment seems to exist. Patients receiving a dose of less than 40 Gy to 70% of the bulb of the penis appear to have a much greater likelihood of maintaining potency. Patients receiving 70 Gy or more to 70% of the bulb of the penis appear to be at very high risk of experiencing radiation-induced impotence (P = 0.03).Conclusions. More studies are needed to confirm these observations. If confirmed, these data suggest that by using three-dimensional-based treatment planning and carefully designed treatment fields, the potency of men treated with radiotherapy might be substantially improved. UROLOGY 57: 955-959, 2001. (C) 2001, Elsevier Science Inc.