Emerging role of m6A RNA methylation in nutritional physiology and metabolism
Emerging role of m6A RNA methylation in nutritional physiology and metabolism
复制标题
m 6 A RNA 甲基化在营养生理学和代谢中的新作用
DOI：
10.1111/obr.12942
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发表时间：
2019-09-02
期刊：
影响因子：
8.9
通讯作者：
Zhong, Xiang
中科院分区：
文献类型：
--
作者：
Wu, Jiamin;Frazier, Katya;Zhong, Xiang
n -6-甲基腺嘌呤（m(6)A）是真核生物mRNA中最常见的内部RNA甲基化类型，在调节基本细胞过程和多种生理功能的基因表达中起着关键作用。最近的证据表明，m(6)A甲基化调节生理和代谢，并且m(6)A越来越多地与各种人类疾病有关，包括肥胖、糖尿病、代谢综合征和癌症。相反，营养和饮食可以调节或逆转基因表达的m(6)A甲基化模式。本文综述了近年来对m(6)A甲基化机制的研究进展，并重点介绍了m(6)A修饰与营养生理和代谢之间的相互作用。
N-6-methyladenine (m(6)A) is the most prevalent type of internal RNA methylation in eukaryotic mRNA and plays critical roles in regulating gene expression for fundamental cellular processes and diverse physiological functions. Recent evidence indicates that m(6)A methylation regulates physiology and metabolism, and m(6)A has been increasingly implicated in a variety of human diseases, including obesity, diabetes, metabolic syndrome and cancer. Conversely, nutrition and diet can modulate or reverse m(6)A methylation patterns on gene expression. In this review, we summarize the recent progress in the study of the m(6)A methylation mechanisms and highlight the crosstalk between m(6)A modification, nutritional physiology and metabolism.