Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort.
Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort.
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DOI：
10.1016/j.cmi.2021.06.023
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Jarrín I
中科院分区：
文献类型：
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作者：
Berenguer J;Díez C;Martín-Vicente M;Micán R;Pérez-Elías MJ;García-Fraile LJ;Vidal F;Suárez-García I;Podzamczer D;Del Romero J;Pulido F;Iribarren JA;Gutiérrez F;Poveda E;Galera C;Izquierdo R;Asensi V;Portilla J;López JC;Arribas JR;Moreno S;González-García J;Resino S;Jarrín I
我们的目的是评估艾滋病毒感染者 (PWH) 中严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的患病率以及与血清阳性和 2019 年无症状冠状病毒病 (COVID-19) 相关的因素。这是在西班牙艾滋病毒研究网络队列中进行的一项横断面研究。参与者是连续 PWH，并于 2020 年 4 月 1 日至 9 月 30 日期间收集血浆。我们测定了血浆中的 SARS-CoV-2 抗体 (Abs)。疾病严重程度（NIH 标准）是通过医疗记录审查以及（如果需要）参与者访谈来评估的。使用多变量逻辑回归分析来确定以下变量中血清阳性的预测因素：性别、年龄、出生国家、教育水平、合并症（高血压、慢性心脏病、糖尿病、非艾滋病相关癌症、慢性肾病、肝硬化）、HIV 获得途径、既往艾滋病史、CD4+ 细胞计数、HIV 病毒载量、核苷/核苷酸逆转录酶抑制剂 (N [t]RTI) 主干、第三种抗逆转录病毒药物类型药物、样本采集月份。在 1076 名感染者中（88.0% 为男性，中位年龄 43 岁，97.7% 接受抗逆转录病毒治疗，中位 CD4+ 688 个细胞/mm3，91.4% 的 HIV 病毒载量检测不到），91 名感染者中检测到 SARS-CoV-2 抗体，血清阳性率为 8.5%（95%CI 6.9-10.3%）。 45 名感染者 (45.0%) 无症状。与 SARS-CoV-2 血清阳性独立相关的变量是拉丁美洲国家与西班牙的出生情况（调整后比值比 (aOR) 2.30，95%CI 1.41–3.76，p < 0.001），以及富马酸替诺福韦二吡呋酯加恩曲他滨 (TDF/FTC) 与作为 N(t)RTI 主干的替诺福韦艾拉酚胺 (TAF)/FTC 治疗（aOR 0.49，95%CI 0.26–0.94，p 0.031）。感染者中的许多 SARS-CoV-2 感染者没有症状，在拉丁美洲国家出生会增加 SARS-CoV-2 血清阳性的风险。我们的分析根据合并症和其他变量进行调整，表明 TDF/FTC 可以预防感染者中的 SARS-CoV-2 感染。
We aimed to assess the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and factors associated with seropositivity and asymptomatic coronavirus disease 2019 (COVID-19) among people with HIV (PWH). This was a cross-sectional study carried out within the cohort of the Spanish HIV Research Network. Participants were consecutive PWH with plasma collected from 1st April to 30th September 2020. We determined SARS-CoV-2 antibodies (Abs) in plasma. Illness severity (NIH criteria) was assessed by a review of medical records and, if needed, participant interviews. Multivariable logistic regression analysis was used to identify predictors of seropositivity among the following variables: sex, age, country of birth, education level, comorbidities (hypertension, chronic heart disease, diabetes mellitus, non-AIDS-related cancer, chronic kidney disease, cirrhosis), route of HIV acquisition, prior AIDS, CD4+ cell count, HIV viral load, nucleoside/nucleotide reverse transcriptase inhibitor (N [t]RTI) backbone, type of third antiretroviral drug, and month of sample collection. Of 1076 PWH (88.0% males, median age 43 years, 97.7% on antiretroviral therapy, median CD4+ 688 cells/mm3, 91.4% undetectable HIV viral load), SARS-CoV-2 Abs were detected in 91 PWH, a seroprevalence of 8.5% (95%CI 6.9–10.3%). Forty-five infections (45.0%) were asymptomatic. Variables independently associated with SARS-CoV-2 seropositivity were birth in Latin American countries versus Spain (adjusted odds ratio (aOR) 2.30, 95%CI 1.41–3.76, p 0.001), and therapy with tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC) versus tenofovir alafenamide (TAF)/FTC as the N(t)RTI backbone (aOR 0.49, 95%CI 0.26–0.94, p 0.031). Many SARS-CoV-2 infections among PWH were asymptomatic, and birth in Latin American countries increased the risk of SARS-CoV-2 seropositivity. Our analysis, adjusted by comorbidities and other variables, suggests that TDF/FTC may prevent SARS-CoV-2 infection among PWH.
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DOI：
10.1093/cid/ciaa1605
发表时间：
2021-10-05
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Geretti AM;Stockdale AJ;Kelly SH;Cevik M;Collins S;Waters L;Villa G;Docherty A;Harrison EM;Turtle L;Openshaw PJM;Baillie JK;Sabin CA;Semple MG
通讯作者：
Semple MG
影响因子：
4.4
作者：
Chien M;Anderson TK;Jockusch S;Tao C;Li X;Kumar S;Russo JJ;Kirchdoerfer RN;Ju J
通讯作者：
Ju J
影响因子：
39.2
作者：
del Amo, Julia;Polo, Rosa;Hernan, Miguel A.
通讯作者：
Hernan, Miguel A.
影响因子：
105.7
作者：
Greenland, Sander;Mansournia, Mohammad Ali;Altman, Douglas G.
通讯作者：
Altman, Douglas G.
DOI：
10.1097/qai.0000000000002423
发表时间：
2020-09-01
影响因子：
3.6
作者：
Karmen-Tuohy, Savannah;Carlucci, Philip M.;Rahimian, Joseph
通讯作者：
Rahimian, Joseph