Diagnostic Utility of TUNEL Staining for Degenerative Keratoacanthoma Requiring Pathologic Differentiation from Seborrheic Keratosis.
Diagnostic Utility of TUNEL Staining for Degenerative Keratoacanthoma Requiring Pathologic Differentiation from Seborrheic Keratosis.
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DOI：
10.1159/000529728
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发表时间：
2023-01
影响因子：
0.9
通讯作者：
中科院分区：
文献类型：
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2 名老年女性出现肿瘤，其临床表现表现为典型的角化棘皮瘤，但病理表现类似于脂溢性角化病。除这2例外，我们还比较了4例病例的病理结果，角化棘皮瘤和脂溢性角化病各1例，其临床和组织病理学均具有典型性。这两个病例和典型的角化棘皮瘤通过末端脱氧核苷酸转移酶dUTP缺口末端标记(TUNEL)染色显示细胞凋亡和细胞毒性T细胞浸润。失代偿期的角化棘皮瘤在组织学上可能与脂溢性角化病相似。 TUNEL 染色有助于诊断褪色角化棘皮瘤。
Tumors developed in 2 old women presented with pathological findings similar to seborrheic keratosis, although the clinical feature of tumor showed typical keratoacanthoma. In addition to these two cases, we compared the pathological findings of a total of four cases, one case each of keratoacanthoma and seborrheic keratosis, which were clinically and histopathological typical. These two cases and the typical keratoacanthoma showed cell apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and infiltration of cytotoxic T cells. The keratoacanthoma in the decompensated stage may be histologically similar to seborrheic keratosis. TUNEL staining can help in the diagnosis of fading keratoacanthoma.