DEADPAN, AN ESSENTIAL PAN NEURAL GENE IN DROSOPHILA, ENCODES A HELIX LOOP HELIX PROTEIN SIMILAR TO THE HAIRY GENE-PRODUCT
DEADPAN, AN ESSENTIAL PAN NEURAL GENE IN DROSOPHILA, ENCODES A HELIX LOOP HELIX PROTEIN SIMILAR TO THE HAIRY GENE-PRODUCT
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DOI：
10.1101/gad.6.11.2137
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发表时间：
1992-11-01
影响因子：
10.5
通讯作者：
JAN, YN
中科院分区：
文献类型：
--
作者：
BIER, E;VAESSIN, H;JAN, YN
果蝇的神经前体细胞在其形成的早期就获得了自身特性。为了确定是否所有神经前体细胞都共享一套遗传机制（也许是为了控制所有神经元共有的分化特性），我们使用增强子诱捕法来鉴定几个在所有神经元和/或其前体细胞中表达的基因（泛神经基因）。其中一个泛神经基因是“无表情”（deadpan），它编码一种螺旋 - 环 - 螺旋蛋白，与分节基因“多毛”（hairy）的产物密切相关。“无表情”的功能对生存能力至关重要，并且可能参与神经元的功能性分化而非形态分化。
Neural precursor cells in Drosophila acquire their identity early during their formation. In an attempt to determine whether all neural precursors share a set of genetic machinery, perhaps to control properties of differentiation common to all neurons, we used the enhancer-trap method to identify several genes (pan-neural genes) that are expressed in all neurons and/or their precursors. one of the pan-neural genes is deadpan, which encodes a helix-loop-helix protein closely related to the product of the segmentation gene hairy. The function of deadpan is essential for viability and is likely to be involved in the functional rather than the morphological differentiation of neurons.