Sensitive Response to Low-Frequency Cochlear Distortion Products in the Auditory Midbrain
Sensitive Response to Low-Frequency Cochlear Distortion Products in the Auditory Midbrain
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DOI：
10.1152/jn.90805.2008
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发表时间：
2009-03-01
影响因子：
2.5
通讯作者：
Koessl, Manfred
中科院分区：
文献类型：
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作者：
Abel, Cornelius;Koessl, Manfred
Abel C，Kossl M.听觉中脑对低频耳蜗畸变产物的敏感反应。神经生理学杂志101：1560-1574，2009年。首次发表于2008年11月26日; doi：10.1152/jn.90805.2008。在具有若干频率分量的听觉刺激期间，失真产物（DP）作为非线性耳蜗放大的副产品而产生。在产生之后，DP能量被重新发射到耳道中，在耳道中其可以被测量为DP耳声发射（DPOAE），并且其还在与DP频率相关的耳蜗位置处引起兴奋性反应。我们测量了91下丘（IC）神经元在沙土鼠在双音刺激的频率远高于单位的感受野，但足以产生一个独特的失真产品（F2-F1或2F 1-F2）在单位的特征频率（CF）的反应。神经元对DP的反应可以通过同时测量DP频率>1.3 kHz的DPOAE来解释。对于DP频率
Abel C, Kossl M. Sensitive response to low-frequency cochlear distortion products in the auditory midbrain. J Neurophysiol 101: 1560-1574, 2009. First published November 26, 2008; doi:10.1152/jn.90805.2008. During auditory stimulation with several frequency components, distortion products (DPs) are generated as byproduct of nonlinear cochlear amplification. After generated, DP energy is reemitted into the ear channel where it can be measured as DP otoacoustic emission (DPOAE), and it also induces an excitatory response at cochlear places related to the DP frequencies. We measured responses of 91 inferior colliculus (IC) neurons in the gerbil during two-tone stimulation with frequencies well above the unit's receptive field but adequate to generate a distinct distortion product (f2-f1 or 2f1-f2) at the unit's characteristic frequency (CF). Neuronal responses to DPs could be accounted for by the simultaneously measured DPOAEs for DP frequencies >1.3 kHz. For DP frequencies