Prognostic value of thrombocytosis in renal cell carcinoma
Prognostic value of thrombocytosis in renal cell carcinoma
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DOI：
10.1016/s0022-5347(05)00526-4
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发表时间：
2006-03-01
影响因子：
6.6
通讯作者：
Patard, JJ
中科院分区：
文献类型：
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作者：
Bensalah, K;Leray, E;Patard, JJ
目的：我们相关的血小板计数肾肿瘤的特点，并评估了潜在的预后价值血小板增多症在本地化和转移tumors.Materials和方法：共804例肾肿瘤手术在2个法国中心被列入本研究。记录所有病例的TNM分期、Fuhrman分级、肿瘤大小、淋巴结浸润、ECOG评分、组织学亚型和血小板计数。采用Kaplan-Meier法对生存率进行比较，并采用考克斯模型进行多因素分析。结果：患者组中男性538例（66.9%），女性266例（33%）（比例为2.02）。中位年龄为62岁。T1期284例（35.3%），T2期116例（14.4%），T3期387例（48.1%），T4期17例（2.1%）。分别有112例（13.9%）和126例（15.7%）患者出现淋巴结和转移性浸润。血小板计数与T分期（p < 0.001）、Fuhrman分级（p < 0.001）、肿瘤大小（p <0.001）、淋巴结浸润（p < 0.001）和远处转移（p = 0.01）密切相关。在单变量分析中，所有研究的因素均显著预测生存率（p = 0.0001）。血小板增多症对局限性（P
Purpose: We correlated platelet count to renal tumor characteristics, and evaluated the potential prognostic value of thrombocytosis in localized and metastatic tumors.Materials and Methods: A total of 804 patients operated on for a renal tumor in 2 French centers were included in this study. In all cases TNM stage, Fuhrman grade, tumor size, nodal invasion, ECOG score, histological subtype and platelet count were recorded. Survival estimates were compared with the Kaplan-Meier method and multivariate analysis was performed using a Cox model.Results: There were 538 (66.9%) males and 266 (33%) females (ratio 2.02) in the patient group. Median age was 62 years. T stages were T1, T2, T3 and T4 in 284 (35.3%),116 (14.4%), 387 (48.1%) and 17 (2.1%), respectively. There were 112 (13.9%) and 126 (15.7%) patients with nodal and metastatic invasion, respectively. Platelet count was strongly correlated with T stage (p < 0.001), Fuhrman grade (p < 0.001), tumor size (p < 0.001), nodal invasion (p < 0.001) and the presence of distant metastasis (p = 0.01). In univariate analysis all studied factors were significantly predictive of survival (p = 0.0001). Thrombocytosis had an impact on prognosis in localized (p