Non-canonical roles of ATG8 for TFEB activation
Non-canonical roles of ATG8 for TFEB activation
复制标题
ATG8 在 TFEB 激活中的非典型作用
DOI：
10.1042/bst20210813
复制
发表时间：
2022
影响因子：
3.9
通讯作者：
Yoshimori Tamotsu
中科院分区：
文献类型：
--
作者：
Nakamura Shuhei;Akayama Shiori;Yoshimori Tamotsu
自噬是一种进化上保守的细胞质降解途径，其中自噬体的双膜结构将细胞质物质隔离并将其递送至溶酶体进行降解。自噬相关蛋白（autophagyrelated protein，ATG）参与了自噬过程的各个环节。ATG8是一种泛素样蛋白，在自噬过程中起着关键作用。ATG8在诱导自噬时直接缀合在自噬体膜的脂质上，从而为监测和分析自噬过程提供了良好的标记物。然而，最近的发现表明，ATG8具有自噬独立的非经典功能，并且ATG8阳性结构并不总是自噬体。本文简要综述了ATG8的经典和非经典作用，并介绍了ATG8激活转录因子EB（TFEB）的新功能，TFEB是溶酶体损伤过程中自噬和溶酶体功能的主要转录因子。
Autophagy is an evolutionally conserved cytoplasmic degradation pathway in which the double membrane structure, autophagosome sequesters cytoplasmic material and delivers them to lysosomes for degradation. Many autophagy related (ATG) proteins participate in the regulation of the several steps of autophagic process. Among ATGs, ubiquitin-like protein, ATG8 plays a pivotal role in autophagy. ATG8 is directly conjugated on lipid in autophagosome membrane upon induction of autophagy thus providing a good marker to monitor and analyze autophagy process. However, recent discoveries suggest that ATG8 has autophagy independent non-canonical functions and ATG8 positive structures are not always autophagosomes. This review briefly overviews canonical and non-canonical roles of ATG8 and introduce novel function of ATG8 to activate Transcriptional Factor EB(TFEB), a master transcription factor of autophagy and lysosome function during lysosomal damage.