Synergistic Effect of Surface-Modified MgO and Chitin Whiskers on the Hydrolytic Degradation Behavior of Injection Molding Poly(L-lactic acid)
Synergistic Effect of Surface-Modified MgO and Chitin Whiskers on the Hydrolytic Degradation Behavior of Injection Molding Poly(L-lactic acid)
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表面改性MgO和甲壳素晶须对注塑聚L-乳酸水解降解行为的协同作用
DOI：
10.1021/acsbiomaterials.8b01629
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发表时间：
2019
影响因子：
--
通讯作者：
Luo Binghong
中科院分区：
文献类型：
--
作者：
Wen Wei;Liu Kun;Zou Ziping;Zhou Changren;Luo Binghong
为了调节聚l-乳酸（PLLA）作为骨内固定材料的降解行为，本研究通过注射成型将表面接枝氧化镁和几丁质晶须（g-MgOs和g- chns）联合或单独添加到PLLA中。制备的二元或三元复合材料在37.5℃，pH值为7.4的PBS溶液中体外降解。系统地考虑了样品在降解过程中质量、pH值、表面形貌、结晶性能、熔化行为和力学性能的变化。结果表明，g- mgo加速了复合材料的早期降解，而g- chn对复合材料的后期降解起调节作用。同时加入g- mgo和g- chns可以维持复合材料早期的力学性能，但在后期促进复合材料的降解，这表明可以在一定程度上调节PLLA基体的降解行为。g- mgos /g-CHNs/PLLA复合材料的可调节降解行为有利于其作为骨内固定植入物的应用。
To regulate the degradation behavior of poly(l-lactic acid) (PLLA) for its use as a bone internal fixation material, surface grafted magnesium oxide and chitin whiskers (g-MgOs andg-CHNs) were added to PLLA in combination or separately via injection molding in this study. The as-prepared binary or ternary composites were degraded in vitro in PBS solution with a pH value of 7.4 at 37.5 °C. The variations in mass, pH value, surface morphology, crystallization performance, melting behavior, and mechanical properties of the samples during the degradation course were systemically considered. The results revealed that theg-MgOs accelerated the early degradation of the composite, while theg-CHNs played a regulatory role in the later degradation of the composite. Simultaneously addingg-MgOs andg-CHNs can maintain the mechanical properties of the composite at an early stage but promote the degradation of the composite at a later stage, which suggests that the degradation behavior of the PLLA matrix could be regulated to some extent. This tunable degradation behavior of theg-MgOs/g-CHNs/PLLA composite is conducive to its application as a bone internal fixation implant.