Association between Chinese visceral adiposity index and metabolic-associated fatty liver disease in Chinese adults with type 2 diabetes mellitus.
Association between Chinese visceral adiposity index and metabolic-associated fatty liver disease in Chinese adults with type 2 diabetes mellitus.
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中国成人2型糖尿病患者内脏脂肪指数与代谢相关脂肪肝的相关性
DOI：
10.3389/fendo.2022.935980
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
目的 本研究的目的是确定中国成人 2 型糖尿病 (T2DM) 患者内脏肥胖指数 (CVAI) 与代谢相关脂肪性肝病 (MAFLD) 的相关性。材料/方法 在这项横断面研究中，收集并分析了有关社会人口特征、实验室测试结果、共存疾病和药物治疗的数据。使用多变量逻辑回归分析来检查 CVAI 和 MAFLD 之间的相关性。为了研究连续尺度上的 CVAI 与 MAFLD 之间的相关性，使用了限制三次样条 (RCS)。结果 本研究共有 679 名参与者。女性参与者 251 名，男性参与者 428 名，中位年龄 55 岁。在多变量逻辑回归模型中，调整了舒张压、糖尿病病程、糖化血红蛋白、血红蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、γ-谷氨酰转移酶、白蛋白、血尿素氮、总胆固醇、低密度脂蛋白胆固醇、他汀类药物使用和二甲双胍使用，发现MAFLD的比值比从CVAI最低四分位数到最高四分位数明显增加（P趋势值 < 0.001)。此外，RCS 曲线显示 CVAI 和 MAFLD 之间呈正相关。结论 CVAI与MAFLD呈正相关，在临床2型糖尿病患者中可能是对MAFLD具有诊断价值的指标。
Objective The purpose of the study was to determine the correlation of the Chinese visceral adiposity index (CVAI) with metabolic-associated fatty liver disease (MAFLD) in Chinese adults with type 2 diabetes mellitus (T2DM). Materials/methods In this cross-sectional study, data on sociodemographic characteristics, laboratory test results, coexisting diseases, and medical therapy were collected and analyzed. Multivariate logistic regression analyses were used to examine the correlation between CVAI and MAFLD. In order to investigate the correlation between CVAI on a continuous scale and MAFLD, a restricted cubic spline (RCS) was used. Results A total of 679 participants were included in this study. There were 251 female participants and 428 male participants, with a median age of 55 years. In the multivariate logistic regression model, diastolic blood pressure, duration of diabetes, glycated hemoglobin, hemoglobin, alanine transaminase, aspartate aminotransferase, gamma -glutamyl transferase, albumin, blood urea nitrogen, total cholesterol, low-density lipoprotein cholesterol, statin use and metformin use were adjusted, and an evident increase in the odds ratios of MAFLD from the lowest to the highest CVAI quartile was found (P value for trend < 0.001). Moreover, the RCS curves revealed a positive correlation between CVAI and MAFLD. Conclusions The CVAI is positively correlated with MAFLD and may be an indicator with diagnostic value for MAFLD in clinical practice in type 2 diabetic patients.