Relative memory deficits in recurrent versus first-episode major depression on a word-list learning task
Relative memory deficits in recurrent versus first-episode major depression on a word-list learning task
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DOI：
10.1037/0894-4105.13.4.557
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发表时间：
1999-10-01
期刊：
影响因子：
2.4
通讯作者：
Bornstein, RA
中科院分区：
文献类型：
--
作者：
Basso, MR;Bornstein, RA
尽管记忆缺陷与严重的抑郁障碍有关，但很少有研究确定哪些患者特征可以预测损害。由于复发性抑郁症似乎与更严重的大脑功能障碍有关，本研究测试了复发性抑郁症患者的记忆功能是否比首发抑郁症患者更差。两组青壮年、非精神病、抑郁症住院患者(20例单发[SE]和46例反复发作[RE])在更广泛的神经心理测试中接受了加利福尼亚语言学习测试。这两组人在年龄、教育程度、估计智商、抑郁严重程度和人口构成方面是相同的。RE组表现出相对于SE组和已发表的常模的记忆缺陷，但在整个电池中没有发现其他显著的差异。数据表明，记忆表现异常与复发性抑郁症有关，而记忆缺陷在首发抑郁症患者中并不明显。
Although memory deficits are associated with major depressive disorder, few studies have identified which patient characteristics predict impairment. Because recurrent depression appears related to more severe cerebral dysfunction, the present study tested whether recurrent depressed individuals have worse memory function than first-episode depressed individuals. Two groups of young-adult, nonpsychotic, depressed inpatients (20 single episode [SE] and 46 recurrent episode [RE]) were administered the California Verbal Learning Test within a broader battery of neuropsychological tests. The groups were equivalent in age, education, estimated IQ, severity of depression, and demographic composition. The RE group demonstrated memory deficits relative to both the SE group and published norms, but no other significant difference was found across the battery. Data indicate that abnormal memory performance is associated with recurrent depression, whereas memory deficits are not prominent in first-episode depressed individuals.