A survey of the outcome of prophylaxis, on-demand treatment or combined treatment in 18-35-year old men with severe haemophilia in six countries
A survey of the outcome of prophylaxis, on-demand treatment or combined treatment in 18-35-year old men with severe haemophilia in six countries
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DOI：
10.1111/j.1365-2516.2012.02934.x
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Prihodova, L.
中科院分区：
文献类型：
--
作者：
Noone, D.;O'Mahony, B.;Prihodova, L.
已经发表了一些关于预防性治疗成人血友病的益处的研究。然而，在许多国家，由于财政限制，它被认为是可选的。这项调查是为了检查预防的长期效果和成年后治疗的持续益处。来自加拿大（N = 40）、法国（N = 14）、爱尔兰（N = 17）、荷兰（N = 16）、波兰（N = 24）和英国（N = 13）的124名男性（26.9±4.6岁）自我评估健康相关数据和EQ-5D健康效用问卷。应答者被分为四组：按需，= 50%生命预防，预防。总体而言，长期预防可降低目标关节的存在
A number of studies have been published on the benefits of prophylactic treatment in adults with haemophilia. However, in many countries, it is considered as optional due to financial constraints. This survey was carried out to examine the long-term effects of prophylaxis and the continuing benefit of the treatment into adulthood. Self-assessed health-related data and the EQ-5D questionnaire measuring health utility were collected from 124 men (26.9 +/- 4.6 years) from Canada (N = 40), France (N = 14), Ireland (N = 17), the Netherlands (N = 16), Poland (N = 24) and the UK (N = 13). The respondents were split into four groups: On-Demand, = 50% life on prophylaxis, Prophylaxis. Overall, long-term prophylaxis results in lower presence of target joints (P