HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.
HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.
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DOI：
10.1016/j.coi.2013.11.005
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发表时间：
2014-02
影响因子：
7
通讯作者：
Stern LJ
中科院分区：
文献类型：
--
作者：
Mellins ED;Stern LJ
II类MHC分子在内体腔室中的肽负载是由HLA-DM调节的。HLA-DO调节HLA-DM功能，影响细胞表面与T细胞相互作用的mhc结合表位谱。在此，我们总结并讨论了HLA-DM和HLA-DO的分子机制及其在免疫应答中的作用的最新进展。主要发现是期待已久的HLA-DM及其II类底物和HLA-DO复合物结构，以及在缺乏HLA-DO的小鼠中观察到一种新的表型-自身免疫结合免疫缺陷。我们还强调了在我们对这对蛋白质及其分子生物学和免疫生物学的知识中存在差距的几个领域。
Peptide loading of class II MHC molecules in endosomal compartments is regulated by HLA-DM. HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound epitopes presented at the cell surface for interaction with T cells. Here, we summarize and discuss recent progress in investigating the molecular mechanisms of action of HLA-DM and HLA-DO and in understanding their roles in immune responses. Key findings are the long-awaited structures of HLA-DM in complex with its class II substrate and with HLA-DO, and observation of a novel phenotype - autoimmunity combined with immunodeficiency - in mice lacking HLA-DO. We also highlight several areas where gaps persist in our knowledge about this pair of proteins and their molecular biology and immunobiology.
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影响因子：
32.4
作者：
Doebele, RC;Busch, R;Mellins, ED
通讯作者：
Mellins, ED
影响因子：
4.8
作者：
Hoepner, Sabine;Dickhaut, Katharina;Roetzschke, Olaf
通讯作者：
Roetzschke, Olaf
影响因子：
4.4
作者：
Gondré-Lewis, TA;Moquin, AE;Drake, JR
通讯作者：
Drake, JR
DOI：
10.1073/pnas.0306885101
发表时间：
2004-03-23
影响因子：
11.1
作者：
Kim, CY;Quarsten, H;Sollid, LM
通讯作者：
Sollid, LM
影响因子：
32.4
作者：
Liljedahl, M;Winqvist, O;Karlsson, L
通讯作者：
Karlsson, L