Antigens for CD4 and CD8 T Cells in Tuberculosis
Antigens for CD4 and CD8 T Cells in Tuberculosis
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DOI：
10.1101/cshperspect.a018465
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发表时间：
2014-07-01
影响因子：
5.4
通讯作者：
Lewinsohn, Deborah
中科院分区：
文献类型：
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作者：
Arlehamn, Cecilia S. Lindestam;Lewinsohn, David;Lewinsohn, Deborah
由结核分枝杆菌（MTB）感染引起的结核病（TB）是世界范围内发病率和死亡率的重要原因，因此迫切需要改进的疫苗和免疫诊断。CD4（+）和CD8（+）T细胞在宿主对结核病的防御中起重要作用。这些T细胞识别的抗原的定义对于提高对结核病免疫生物学的理解以及疫苗和诊断的开发至关重要。本文综述了结核分枝杆菌感染者中经典HLA I类和II类限制性CD4（+）和CD8（+）T细胞识别的抗原和表位。免疫显性抗原和表位已经使用靶向特定TB蛋白或蛋白类别的方法和通过全基因组发现方法来定义。由经典限制性CD4（+）和CD8（+）T细胞识别的抗原和表位在结核分枝杆菌感染的人中显示出广泛的广度和多样性。
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB. Definition of the antigens recognized by these T cells is critical for improved understanding of the immunobiology of TB and for development of vaccines and diagnostics. Herein, the antigens and epitopes recognized by classically HLA class I- and II-restricted CD4(+) and CD8(+) T cells in humans infected with MTB are reviewed. Immunodominant antigens and epitopes have been defined using approaches targeting particular TB proteins or classes of proteins and by genome-wide discovery approaches. Antigens and epitopes recognized by classically restricted CD4(+) and CD8(+) T cells show extensive breadth and diversity in MTB-infected humans.