A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study.
A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study.
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对两个具有对比冠心病风险的人群进行脂蛋白颗粒的病例对照研究。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
G. Luc
中科院分区：
文献类型：
--
作者：
H. Parra;D. Arveiler;A. Evans;J. Cambou;P. Amouyel;A. Bingham;D. Mcmaster;P. Schaffer;P. Douste;G. Luc
北爱尔兰中年男性的冠心病发病率是法国的三倍多。ECTIM研究以设在贝尔法斯特(北爱尔兰)、斯特拉斯堡(法国东部)、图卢兹(法国西南部)和里尔(法国北部)的世卫组织莫尼卡中心为基础，旨在调查这一显著差异。研究对象为年龄25-的男性心肌梗死患者和从普通人群中抽取的对照组。降血脂药物治疗在法国比在贝尔法斯特频繁得多。“高胆固醇血症”的定义是存在降血脂药物治疗或低密度脂蛋白胆固醇水平高于200毫克/分升，在两个国家的病例中比对照组更常见，但在两个对照组中相似。对非高胆固醇血症受试者的血脂变量进行了深入的研究，包括测量胆固醇组分、甘油三酯、载脂蛋白(Apo)和脂蛋白颗粒(LP)。在北爱尔兰和法国，与对照组相比，患者的高密度脂蛋白胆固醇、载脂蛋白A-I、载脂蛋白A-II、脂蛋白A-I和脂蛋白A-II：A-I的水平较低，而脂蛋白E：B和脂蛋白(A)：B的水平较高。甘油三酯、极低密度脂蛋白胆固醇、载脂蛋白B和脂蛋白C-III：B的水平仅在贝尔法斯特高于对照组。在对照组中，北爱尔兰和法国的胆固醇组分和载脂蛋白的平均水平相似；但北爱尔兰的Lp A-I水平低于法国，Lp E：B和Lp(A)：B的水平高于法国。
The incidence of coronary heart disease (CHD) in middle-aged men is more than three times higher in Northern Ireland than in France. The ECTIM study, which is based on WHO MONICA centers in Belfast (Northern Ireland), Strasbourg (eastern France), Toulouse (southwestern France), and Lille (northern France), has been established to investigate this striking difference. Male patients aged 25-64 years with myocardial infarction (MI) and control subjects sampled from the general population were recruited in the four centers. Hypolipidemic drug treatment was much more frequent in France than in Belfast. "Hypercholesterolemia" defined by the presence of hypolipidemic drug treatment or a low density liproprotein cholesterol level greater than 200 mg/dl was more frequent in cases than in controls in both countries but was similar in both control groups. An in-depth study of lipid variables, including measurements of cholesterol fractions, triglycerides, apolipoproteins (apo), and lipoprotein particles (Lp), was performed in nonhypercholesterolemic subjects. In Northern Ireland and France, patients in comparison with controls had lower levels of high density lipoprotein cholesterol, apo A-I, apo A-II, Lp A-I, and Lp A-II:A-I and higher levels of Lp E:B and Lp(a):B. The levels of triglycerides, very low density lipoprotein cholesterol, apo B, and Lp C-III:B were higher in cases than in controls only in Belfast. In control subjects, the mean levels of cholesterol fractions and apolipoproteins were similar in Northern Ireland and France; however, the level of Lp A-I was lower and the levels of Lp E:B and Lp(a):B were higher in Northern Ireland than in France.(ABSTRACT TRUNCATED AT 250 WORDS)
冠状动脉疾病患者中含有载脂蛋白 A-I 的脂蛋白的粒径分布发生改变。
影响因子：
6.5
作者：
Cheung,MC;Brown,BG;Wolf,AC;Albers,JJ
通讯作者：
Albers,JJ